Effect of transcutaneous auricular vagus nerve stimulation combined with patient-controlled intravenous analgesia on postoperative pain in patients with total knee arthroplasty.

Q3 Medicine

针刺研究 Pub Date : 2025-02-25 DOI:10.13702/j.1000-0607.20231101

Hao-Xun Huang, Xing-He Wang, Yan Zhang, Jin Zhang, Teng Li, Zi-Heng Wang, Yang-Zi Zhu, Li-Wei Wang

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引用次数: 0

Abstract

Objectives: To explore the effect of transcutaneous auricular vagus nerve stimulation (taVNS) combined with patient-controlled intravenous analgesia (PCIA) on postoperative pain in patients undergoing total knee arthroplasty (TKA).

Methods: A total of 140 patients with TKA were randomly divided into the taVNS group (n=70, with 5 dropped-out) and the sham stimulation group (n=70, with 6 dropped-out). The taVNS group received taVNS at the left ear conchae combined with PCIA treatment, while the sham stimulation group received sham taVNS at the left ear conchae combined with PCIA treatment. The time-weighted average (TWA) pain score, visual analogue scale (VAS) score of 1-7 days after surgery, the occurrence of adverse reactions such as nausea, vomiting, skin pruritus, drowsiness, respiratory depression, and the number of PCIA pump compressions within 48 hours after surgery were observed and compared between the 2 groups. The Beck Anxiety Inventory (BAI) scores, Bake Depression Inventory (BDI) scores, and Pittsburgh Sleep Quality Index (PSQI) scores were obtained on the day before surgery and 7 days after surgery.

Results: Compared with the sham stimulation group, the TWA pain score of the taVNS group was significantly decreased at the 7^th day postoperatively (P<0.01), and the VAS scores of the taVNS group were significantly lower than those of the sham stimulation group on postoperative days 3^rd, 4^th, and 5^th (P<0.001, P<0.01, P<0.05), with no statistical significance in VAS scores on postoperative days 1^st, 2^nd, 6^th, and 7^th. Compared with the sham stimulation group, the incidence of nausea and the number of PCIA pump compressions within 48 hours after surgery in the taVNS group was significantly decreased (P<0.05). There was no statistical significance in the differences between the BDI, BAI, and PSQI scores before and after surgery in both groups. PSQI scores in the sham stimulation group and taVNS group were significantly lower than those in the same group 1 day before surgery (P<0.01, P<0.001).

Conclusions: The taVNS combined with PCIA can reduce postoperative pain, the incidence of nausea, and the opioid dosage in TKA patients.

查看原文本刊更多论文

经皮耳迷走神经刺激联合患者自主静脉镇痛对全膝关节置换术患者术后疼痛的影响。

目的：探讨经皮耳迷走神经刺激（taVNS）联合患者自主静脉镇痛（PCIA）对全膝关节置换术（TKA）患者术后疼痛的影响。方法：140例TKA患者随机分为taVNS组（70例，退出5例）和假刺激组（70例，退出6例）。taVNS组在左耳甲壳处进行taVNS联合PCIA治疗，假刺激组在左耳甲壳处进行假taVNS联合PCIA治疗。观察并比较两组患者术后1 ~ 7 d的时间加权平均（TWA）疼痛评分、视觉模拟评分（VAS），以及术后48 h内恶心、呕吐、皮肤瘙痒、嗜睡、呼吸抑制等不良反应的发生情况和PCIA泵按压次数。分别于术前1天和术后7 d进行贝克焦虑量表（BAI）评分、贝克抑郁量表（BDI）评分和匹兹堡睡眠质量指数（PSQI）评分。结果：与假刺激组比较，taVNS组术后第7天（Prd、第4、第5天）TWA疼痛评分明显降低（PPPst、第2、第6、第7天）。与假刺激组比较，taVNS组术后48 h内恶心发生率及PCIA泵按压次数均显著降低（ppp）结论：taVNS联合PCIA可减轻TKA患者术后疼痛、恶心发生率及阿片类药物用量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

针刺研究 Medicine-Medicine (all)

CiteScore

1.30

自引率

0.00%

发文量

期刊介绍： Acupuncture Research was founded in 1976. It is an acupuncture academic journal supervised by the State Administration of Traditional Chinese Medicine, co-sponsored by the Institute of Acupuncture of the China Academy of Chinese Medical Sciences and the Chinese Acupuncture Association. This journal is characterized by "basic experimental research as the main focus, taking into account clinical research and reporting". It is the only journal in my country that focuses on reporting the mechanism of action of acupuncture. The journal has been changed to a monthly journal since 2018, published on the 25th of each month, and printed in full color. The manuscript acceptance rate is about 10%, and provincial and above funded projects account for about 80% of the total published papers, reflecting the latest scientific research results in the acupuncture field and has a high academic level. Main columns: mechanism discussion, clinical research, acupuncture anesthesia, meridians and acupoints, theoretical discussion, ideas and methods, literature research, etc.