A.M. Ruha , M.B. Spyres , R. Culbreth , B. Wolk , C. Hoyte , S. Campleman
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引用次数: 0
Abstract
Background
Some North American rattlesnake venoms and angiotensin converting enzyme inhibitor (ACEI) medications each increase bradykinin levels in humans, with clinical effects attributable to bradykinin described in exposed populations. Influence of ACEI exposure on persons with snake envenomation has not been studied. We used data from the ACMT North American Snakebite Registry (NASBR) to determine if use of ACEI medications at the time of rattlesnake envenomation is associated with increased rate of systemic toxicity.
Methods
Rattlesnake envenomations entered in the NASBR between January 1, 2013 and December 31, 2021 were included. Data extracted included patient demographics, medical history, clinical and laboratory findings, treatments, and outcomes. Patients who use ACE Inhibitors (ACEI group) were compared to patients without ACEI use (No ACEI group). Primary outcomes included systemic venom effects and secondary outcomes included length of stay and total number of antivenom vials administered (for Fab and F (ab')2).
Results
817 rattlesnake envenomations were included. Forty-three (5.3%) were in the ACEI group and 774 (94.7%) in the No ACEI group. There were no differences in time to antivenom or acute hypersensitivity reactions between groups. Hypotension was more frequent in the ACEI group (18.6%) compared to the No ACEI group (6.5%; p = 0.008). Diarrhea also occurred more frequently in the ACEI group (11.6%) compared to the No ACEI group (2.1%; p = 0.003). However, overall systemic toxicity did not significantly differ between the two groups (25.6% ACEI vs. 17.4% no ACEI, p = 0.25).
Conclusions
In the NASBR, patients who use ACEIs are more likely to experience hypotension and/or diarrhea after rattlesnake envenomation than are patients who do not use ACEIs; however, overall systemic toxicity did not significantly differ between the two groups.
期刊介绍:
Toxicon has an open access mirror Toxicon: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. An introductory offer Toxicon: X - full waiver of the Open Access fee.
Toxicon''s "aims and scope" are to publish:
-articles containing the results of original research on problems related to toxins derived from animals, plants and microorganisms
-papers on novel findings related to the chemical, pharmacological, toxicological, and immunological properties of natural toxins
-molecular biological studies of toxins and other genes from poisonous and venomous organisms that advance understanding of the role or function of toxins
-clinical observations on poisoning and envenoming where a new therapeutic principle has been proposed or a decidedly superior clinical result has been obtained.
-material on the use of toxins as tools in studying biological processes and material on subjects related to venom and antivenom problems.
-articles on the translational application of toxins, for example as drugs and insecticides
-epidemiological studies on envenoming or poisoning, so long as they highlight a previously unrecognised medical problem or provide insight into the prevention or medical treatment of envenoming or poisoning. Retrospective surveys of hospital records, especially those lacking species identification, will not be considered for publication. Properly designed prospective community-based surveys are strongly encouraged.
-articles describing well-known activities of venoms, such as antibacterial, anticancer, and analgesic activities of arachnid venoms, without any attempt to define the mechanism of action or purify the active component, will not be considered for publication in Toxicon.
-review articles on problems related to toxinology.
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