Jianlin Zhou, Xueni Lu, Ruirui He, Yanyun Du, Bo Zeng, Lingyun Feng, Ming Yi, Yuan Wang, Chenhui Wang
{"title":"Antifungal immunity: advances in PRR recognition, adaptive responses, and immune-based therapies.","authors":"Jianlin Zhou, Xueni Lu, Ruirui He, Yanyun Du, Bo Zeng, Lingyun Feng, Ming Yi, Yuan Wang, Chenhui Wang","doi":"10.1007/s11427-024-2835-y","DOIUrl":null,"url":null,"abstract":"<p><p>As a common disease in human life, fungal infection poses a serious threat to human life and health. Moreover, owing to the rapid development of the immune escape mechanisms of fungi and the emergence of new drug-resistant fungi, existing therapeutic drugs are no longer able to meet the treatment needs of patients. In particular, the World Health Organization (WHO) published the first Fungal Priority Pathogens List (FPPL) in 2022, further emphasizing that we need to pay more attention to invasive fungal infections. In addition, the WHO has called for increased global investment in fungal infections and the development of antifungal drugs. In this review, we introduce the mechanism by which innate immune cell PRRs recognize fungal pathogen PAMPs, the role of adaptive immune cells in antifungal immunity, fungal infections caused by immune deficiencies, and the latest research progress in immune-based fungal therapies.</p>","PeriodicalId":21576,"journal":{"name":"Science China Life Sciences","volume":" ","pages":""},"PeriodicalIF":8.0000,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Science China Life Sciences","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1007/s11427-024-2835-y","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
As a common disease in human life, fungal infection poses a serious threat to human life and health. Moreover, owing to the rapid development of the immune escape mechanisms of fungi and the emergence of new drug-resistant fungi, existing therapeutic drugs are no longer able to meet the treatment needs of patients. In particular, the World Health Organization (WHO) published the first Fungal Priority Pathogens List (FPPL) in 2022, further emphasizing that we need to pay more attention to invasive fungal infections. In addition, the WHO has called for increased global investment in fungal infections and the development of antifungal drugs. In this review, we introduce the mechanism by which innate immune cell PRRs recognize fungal pathogen PAMPs, the role of adaptive immune cells in antifungal immunity, fungal infections caused by immune deficiencies, and the latest research progress in immune-based fungal therapies.
期刊介绍：
Science China Life Sciences is a scholarly journal co-sponsored by the Chinese Academy of Sciences and the National Natural Science Foundation of China, and it is published by Science China Press. The journal is dedicated to publishing high-quality, original research findings in both basic and applied life science research.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
