A Case of Primary Cutaneous T-Follicular Helper Cell Lymphoma, Follicular-Type.

IF 2.5 4区医学 Q2 PATHOLOGY

Pathology International Pub Date : 2025-03-01 Epub Date: 2025-03-10 DOI:10.1111/pin.70003

Reiji Muto, Hiroaki Miyoshi, Toshihiko Murayama, Koji Makino, Koichi Ohshima

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Abstract

This is a case of primary cutaneous T-follicular helper cell lymphoma, follicular-type. A 99-year-old woman was detected with cutaneous mass located in left greater trochanter area and buttock, which was suspected to be malignant lymphoma. Computed tomography revealed few regional lymph node enlargement. Skin biopsy was performed for diagnosis. Pathologically, diffuse and dense proliferation of medium-sized atypical lymphocytes was observed proliferating with a vague nodular pattern. The immunohistochemical analysis presented that atypical lymphocytes composing vague nodular lesion were positive for CD3, CD4, PD-1, ICOS, BCL6, and CXCL13. Additionally, diffuse medium-sized B-cell proliferation was also observed. The monoclonality of T-cell receptor-gamma and IgVH was confirmed by polymerase chain reaction. Here we described a primary cutaneous case of FTCL. In the 5th edition of the WHO classification, TFH lymphoma is limited to lymph node and there is no consensus regarding the management of extranodal TFH lymphoma. Further accumulation of extranodal counterpart of the cases and clinicopathological examination of extranodal and nodal lesions is desired.

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原发性皮肤t -滤泡辅助细胞淋巴瘤1例。

这是一例原发性皮肤t -滤泡辅助细胞淋巴瘤，滤泡型。一位99岁的女性在左侧大转子区及臀部发现皮肤肿块，怀疑为恶性淋巴瘤。计算机断层扫描显示少量区域淋巴结肿大。进行皮肤活检诊断。病理表现为中等非典型淋巴细胞弥漫性致密增生，呈模糊结节状。免疫组化分析显示，构成模糊结节性病变的非典型淋巴细胞CD3、CD4、PD-1、ICOS、BCL6、CXCL13阳性。此外，还观察到弥漫的中型b细胞增殖。聚合酶链反应证实t细胞受体γ和IgVH的单克隆性。我们在此报告一例原发性皮肤FTCL病例。在WHO第5版分类中，TFH淋巴瘤仅限于淋巴结，对于结外TFH淋巴瘤的治疗尚无共识。需要进一步积累结外对应的病例，并对结外和结内病变进行临床病理检查。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pathology International 医学-病理学

CiteScore

4.50

自引率

4.50%

发文量

102

审稿时长

12 months

期刊介绍： Pathology International is the official English journal of the Japanese Society of Pathology, publishing articles of excellence in human and experimental pathology. The Journal focuses on the morphological study of the disease process and/or mechanisms. For human pathology, morphological investigation receives priority but manuscripts describing the result of any ancillary methods (cellular, chemical, immunological and molecular biological) that complement the morphology are accepted. Manuscript on experimental pathology that approach pathologenesis or mechanisms of disease processes are expected to report on the data obtained from models using cellular, biochemical, molecular biological, animal, immunological or other methods in conjunction with morphology. Manuscripts that report data on laboratory medicine (clinical pathology) without significant morphological contribution are not accepted.