Summary of a Consensus Conference on the Management of Highly Sensitized Multiorgan Transplant Candidates

IF 6.9 2区医学 Q1 MEDICINE, GENERAL & INTERNAL

Mayo Clinic proceedings Pub Date : 2025-04-01 DOI:10.1016/j.mayocp.2025.01.012

Timucin Taner MD, PhD , Scott W. Biggins MD , Nathan Cummins MD , Richard C. Daly MD , Allan B. Dietz PhD , Juliet Emamaullee MD, PhD , Manish J. Gandhi MD , Julie K. Heimbach MD , Jignesh K. Patel MD , Naveen L. Pereira MD , Andrew Rosenbaum MD , Alberto Sanchez-Fueyo MD, PhD , Alexandra Shingina MD , Mark D. Stegall MD , Mauricio A. Villavicencio Theoduloz MD , Joyce W. Wald DO , Sudhir S. Kushwaha MD

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引用次数: 0

Abstract

The number of highly sensitized patients in need of a multiorgan transplant is increasing. Criteria informing their transplant candidacy, approaches to management on the waitlist, and protocols related to alloantibody monitoring vary widely. We convened a consensus conference to discuss these different practices in the United States and the United Kingdom and to review the contemporary outcomes of these challenging cases. A detailed analysis of the data regarding the liver allografts’ immunoprotective effect on simultaneously transplanted other organs was also completed, and the prospect of the use of liver allografts primarily to facilitate transplantation of highly sensitized patients in need of other organs was discussed. The ethical and allocation-related issues about such prospect were debated with a goal to standardize the approach and provide an evidence-based pathway for pre-, peri-, and post-transplantation management for the highly sensitized multiorgan transplantation candidate.

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高度敏感的多器官移植候选人管理共识会议摘要。

需要多器官移植的高度敏感患者的数量正在增加。告知其移植候选资格的标准、候补名单管理方法和与同种异体抗体监测相关的协议差异很大。我们召开了一次共识会议，讨论美国和英国的这些不同做法，并回顾这些具有挑战性的案例的当代结果。并详细分析了同种异体肝移植对同时移植的其他器官的免疫保护作用的相关数据，探讨了同种异体肝移植主要用于促进需要其他器官的高度敏感患者移植的前景。关于这一前景的伦理和分配相关问题进行了讨论，目的是使方法标准化，并为高度敏感的多器官移植候选人的移植前、移植中和移植后管理提供循证途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Mayo Clinic proceedings 医学-医学：内科

CiteScore

16.80

自引率

1.10%

发文量

383

审稿时长

37 days

期刊介绍： Mayo Clinic Proceedings is a premier peer-reviewed clinical journal in general medicine. Sponsored by Mayo Clinic, it is one of the most widely read and highly cited scientific publications for physicians. Since 1926, Mayo Clinic Proceedings has continuously published articles that focus on clinical medicine and support the professional and educational needs of its readers. The journal welcomes submissions from authors worldwide and includes Nobel-prize-winning research in its content. With an Impact Factor of 8.9, Mayo Clinic Proceedings is ranked #20 out of 167 journals in the Medicine, General and Internal category, placing it in the top 12% of these journals. It invites manuscripts on clinical and laboratory medicine, health care policy and economics, medical education and ethics, and related topics.