The ratio of perirenal fat thickness to renal parenchymal thickness, a novel indicator of fat accumulation associated with kidney stones.

IF 3.9 2区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Lipids in Health and Disease Pub Date : 2025-03-07 DOI:10.1186/s12944-025-02497-7

Dekai Hu, Guoxiang Li, Defeng Ge, Leilei Ke, Hongmin Shu, Yang Chen, Zongyao Hao

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引用次数: 0

Abstract

Background: Metabolic syndrome, identified by increased visceral fat accumulation, is notably linked to a heightened risk of nephrolithiasis. Despite this, the influence of the perirenal fat thickness relative to renal parenchymal thickness on kidney stones (KS) development remains ambiguous. This study investigated the clinical characteristics of perirenal fat on both the left and right sides and explored the association between the aforementioned ratio and KS.

Methods: The study enrolled 161 participants who underwent computed tomography (CT) scans. In this study, kidneys were segregated into two categories based on the presence of stones: stone-bearing and non-stone-bearing for both the left and right kidneys. Perirenal fat parameters were extracted from the imaging workstation database. Both univariate and multivariate logistic regression analyses were conducted to explore the correlation between metrics related to perirenal fat and the occurrence of KS.

Results: Among the 161 participants, significant variations in perirenal fat were observed between the left and right kidneys, as well as between genders. Subsequent to adjustments for several confounding variables, the multivariable logistic regression model demonstrated a significant correlation between the ratio of perirenal fat thickness to renal parenchymal thickness and stone bearing kidney (P < 0.001).

Conclusions: The ratio of perirenal fat thickness to renal parenchymal thickness was significantly correlated with kidney stones.

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肾周脂肪厚度与肾实质厚度之比，肾结石相关脂肪堆积的新指标。

背景：代谢综合征，由内脏脂肪堆积增加确定，与肾结石风险增加明显相关。尽管如此，肾周脂肪厚度相对于肾实质厚度对肾结石（KS）发展的影响仍不明确。本研究考察了左右两侧肾周脂肪的临床特征，并探讨了上述比值与KS的关系。方法：该研究招募了161名接受计算机断层扫描（CT）的参与者。在本研究中，肾脏根据结石的存在分为两类：左肾和右肾的含石和非含石。从成像工作站数据库中提取肾周脂肪参数。采用单因素和多因素logistic回归分析，探讨肾周脂肪相关指标与KS发生的相关性。结果：在161名参与者中，观察到左肾和右肾以及性别之间肾周脂肪的显著差异。在对多个混杂变量进行校正后，多变量logistic回归模型显示肾周脂肪厚度与肾实质厚度之比与肾结石有显著相关性(P)。结论：肾周脂肪厚度与肾实质厚度之比与肾结石有显著相关性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Lipids in Health and Disease 生物-生化与分子生物学

CiteScore

7.70

自引率

2.20%

发文量

122

审稿时长

3-8 weeks

期刊介绍： Lipids in Health and Disease is an open access, peer-reviewed, journal that publishes articles on all aspects of lipids: their biochemistry, pharmacology, toxicology, role in health and disease, and the synthesis of new lipid compounds. Lipids in Health and Disease is aimed at all scientists, health professionals and physicians interested in the area of lipids. Lipids are defined here in their broadest sense, to include: cholesterol, essential fatty acids, saturated fatty acids, phospholipids, inositol lipids, second messenger lipids, enzymes and synthetic machinery that is involved in the metabolism of various lipids in the cells and tissues, and also various aspects of lipid transport, etc. In addition, the journal also publishes research that investigates and defines the role of lipids in various physiological processes, pathology and disease. In particular, the journal aims to bridge the gap between the bench and the clinic by publishing articles that are particularly relevant to human diseases and the role of lipids in the management of various diseases.