Mapping the Knowledge Landscape of and Emerging Future Trends in Stem Cell Therapy for Osteoarthritis: A Bibliometric Analysis of the Literature From 1998 to 2024.
Zhishou Meng, Dongqin He, Honggang Wang, Lijuan Ma, Le Guan, Yongning Ai, Jianxin Yang, Ruxing Liu
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引用次数: 0
Abstract
Objective: The purpose of this study was to conduct a bibliometric analysis of the literature on stem cell therapy for osteoarthritis (OA) to visualize recent developments, identify hot spots, and determine trends in the field.
Background: OA is a chronic disease that affects the joints and their surrounding tissues, leading to progressive damage to the articular cartilage and ultimately to the subchondral bone and the surrounding synovial structures. OA is a disabling disease with an increasing incidence and prevalence in the general population. Modulation of immunity and inflammation and improvement of cell survival and differentiation through multidirectional differentiation of stem cells is a potential strategy for the treatment of OA.
Methods: We searched for publications on "stem cell therapy for osteoarthritis" in the Web of Science (WOS) core collection database from 1998-2024 and summarized the results, including year of publication, country, institution, author, and collaborative network generated using VOSviewer and Citespace. In addition, research trends were identified. Finally, we summarized the hot topics and identified future research trends.
Results: This study ultimately included 2341 valid papers, with a trend toward a gradual increase in the number of publications over time. The country, institution, author, and journal with the highest number of publications and citations were China, the University of California system, Sekiya I, and Osteoarthritis and Cartilage, respectively. High-frequency keyword clusters included cell therapy, stem cells, tissue engineering, and extracellular vesicles.
Conclusion: Through visualization and analysis, we elucidated the trends and research hotspots in the field over the past five years. The analysis revealed that stem cell transplantation and exosome therapy for OA may be the focus of future research. This study lays the foundation for future research and clinical work on stem cell therapy in this field.
目的：本研究的目的是对骨关节炎（OA）干细胞治疗的文献进行文献计量学分析，以可视化最近的发展，识别热点，并确定该领域的趋势。背景：骨性关节炎是一种影响关节及其周围组织的慢性疾病，可导致关节软骨进行性损伤，最终损害软骨下骨和周围滑膜结构。骨关节炎是一种致残性疾病，在普通人群中发病率和患病率都在增加。通过干细胞的多向分化调节免疫和炎症，改善细胞存活和分化是治疗OA的潜在策略。方法：在Web of Science （WOS）核心馆藏数据库中检索1998-2024年关于“干细胞治疗骨关节炎”的出版物，并汇总结果，包括发表年份、国家、机构、作者以及使用VOSviewer和Citespace生成的协作网络。此外，还确定了研究趋势。最后，对研究热点进行了总结，并对未来的研究趋势进行了展望。结果：本研究最终纳入有效论文2341篇，随着时间的推移，论文发表数量呈逐渐增加的趋势。发表论文和被引用次数最多的国家、机构、作者和期刊分别是中国、加州大学系统、Sekiya I和Osteoarthritis and Cartilage。高频关键词集群包括细胞治疗、干细胞、组织工程和细胞外囊泡。结论：通过可视化和分析，总结了近5年来该领域的发展趋势和研究热点。分析表明，干细胞移植和外泌体治疗OA可能是未来研究的重点。本研究为今后干细胞治疗在该领域的研究和临床工作奠定了基础。
期刊介绍：
The Journal of Multidisciplinary Healthcare (JMDH) aims to represent and publish research in healthcare areas delivered by practitioners of different disciplines. This includes studies and reviews conducted by multidisciplinary teams as well as research which evaluates or reports the results or conduct of such teams or healthcare processes in general. The journal covers a very wide range of areas and we welcome submissions from practitioners at all levels and from all over the world. Good healthcare is not bounded by person, place or time and the journal aims to reflect this. The JMDH is published as an open-access journal to allow this wide range of practical, patient relevant research to be immediately available to practitioners who can access and use it immediately upon publication.
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