Dietary Gluten Intake and Cardiovascular Disease Mortality in Japanese Adults in the Takayama Study

IF 3.7 3区医学 Q2 NUTRITION & DIETETICS

Journal of Nutrition Pub Date : 2025-06-01 DOI:10.1016/j.tjnut.2025.03.005

Michiko Tsuji , Keiko Wada , Michiyo Yamakawa , Masaaki Sugino , Tomoka Mori , Chisato Nagata

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引用次数: 0

Abstract

Background

There is growing attention toward the gluten-free diet in Japan, in spite of a low prevalence of celiac disease and high consumption of rice.

Objectives

The present study examined whether gluten intake is associated with an increased risk of cardiovascular disease (CVD) mortality in Japanese adults.

Methods

In 1992, 13,355 men and 15,724 women, ≥35 y of age, in the Takayama study, completed a self-administered questionnaire. Gluten intake was estimated using a food frequency questionnaire as a baseline. Mortality was ascertained during 16 y of follow-up. Hazard ratios (HRs) and 95% confidence intervals (CIs) for CVD mortality were calculated according to gluten intake quartiles.

Results

During 16.1 y of follow-up, 775 CVD deaths in men and 903 CVD deaths in women occurred. Compared with the lowest quartile of intake, the highest quartile of gluten intake was significantly associated with a decreased risk of CVD mortality after controlling for age, sex, and other covariates (HR = 0.73; 95% CI: 0.62, 0.86, P-trend = 0.0003).

Conclusions

Our data showed a significant inverse association between gluten intake and CVD mortality. The present study does not support the notion that gluten avoidance should have a beneficial effect on CVD mortality.

查看原文本刊更多论文

在Takayama研究中，日本成年人的饮食谷蛋白摄入和心血管疾病死亡率。

背景：在日本，尽管乳糜泻患病率低，大米消费量高，但人们对无麸质饮食的关注越来越多。目的：本研究调查了麸质摄入是否与日本成年人心血管疾病（CVD）死亡风险增加有关。方法：1992年，在Takayama研究中，年龄在35岁及以上的13355名男性和15724名女性完成了一份自我管理的问卷。使用食物频率问卷作为基线估计谷蛋白摄入量。在16年的随访中确定了死亡率。根据谷蛋白摄入四分位数计算心血管疾病死亡率的风险比（hr）和95% ci。结果：在16.1年的随访期间，男性心血管疾病死亡775例，女性心血管疾病死亡903例。与最低四分位数的摄入相比，在控制了年龄、性别和其他协变量后，麸质摄入最高四分位数与心血管疾病死亡率降低的风险显著相关(HR = 0.73；95% CI: 0.62-0.86, P-trend = 0.0003)。结论：我们的数据显示谷蛋白摄入与心血管疾病死亡率之间存在显著的负相关。目前的研究不支持麸质避免对心血管疾病死亡率有有益影响的观点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Nutrition 医学-营养学

CiteScore

7.60

自引率

4.80%

发文量

260

审稿时长

39 days

期刊介绍： The Journal of Nutrition (JN/J Nutr) publishes peer-reviewed original research papers covering all aspects of experimental nutrition in humans and other animal species; special articles such as reviews and biographies of prominent nutrition scientists; and issues, opinions, and commentaries on controversial issues in nutrition. Supplements are frequently published to provide extended discussion of topics of special interest.