Intermittent Fasting Regimes Reduce Gingival Inflammation: A Three-Arm Clinical Trial

IF 5.8 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Clinical Periodontology Pub Date : 2025-03-09 DOI:10.1111/jcpe.14151

C. L. Pappe, J. Maetschker, S. Dujardin, B. Peters, O. Pivovarova-Ramich, F. Kandil, A. Michalsen, C. Breinlinger, N. Steckhan, D. Koppold, H. Dommisch

{"title":"Intermittent Fasting Regimes Reduce Gingival Inflammation: A Three-Arm Clinical Trial","authors":"C. L. Pappe, J. Maetschker, S. Dujardin, B. Peters, O. Pivovarova-Ramich, F. Kandil, A. Michalsen, C. Breinlinger, N. Steckhan, D. Koppold, H. Dommisch","doi":"10.1111/jcpe.14151","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Aim</h3>\n \n <p>To evaluate the effect of religious Bahá'í dry fasting (BF) or 16:8 time-restricted eating (TRE) compared with a regular diet (CG) on periodontal parameters during a modified experimentally induced gingivitis.</p>\n </section>\n \n <section>\n \n <h3> Material and Methods</h3>\n \n <p>All participants were asked to refrain from oral hygiene (3 sextant) for 9 days (T1–T2) and were followed for a total of 19 days (T3) while adhering to fasting or a regular diet and resuming oral hygiene. The primary outcome was bleeding on probing in the test sextant (BOP_s), Rustogi plaque index (RPI), gingival crevicular fluid (GCF), blood pressure (BP), body weight (BW), HbA1c and C-reactive protein (CRP) were measured (T1–T3) and ANCOVA and post hoc comparison were applied.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Sixty-six healthy participants were recruited. Forty-three were randomly assigned to TRE (<i>n</i> = 22) and CG (<i>n</i> = 21), while 23 followed BF, avoiding food and drinks during the day. At T2, BF demonstrated significantly less increase in BOP_s, and GCF increased in CG only. Analysis revealed significant differences in change for BOP_s between BF and CG (−9.48% [−17.18; −1.79]) and BF and TRE (−9.19% [−15.07; −3.32]) as well as for GCF between BF and CG (−0.06 μL [−7.22; −0.66]) and TRE and CG (−0.08 μL [−0.17; −0.00]).</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>This study indicates beneficial effects of different fasting protocols on oral experimental gingivitis and metabolic parameters, but results are limited by randomisation issues and potential bias in the BF group.</p>\n </section>\n </div>","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"52 5","pages":"681-694"},"PeriodicalIF":5.8000,"publicationDate":"2025-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcpe.14151","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Clinical Periodontology","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/jcpe.14151","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}

引用次数: 0

Abstract

Aim

To evaluate the effect of religious Bahá'í dry fasting (BF) or 16:8 time-restricted eating (TRE) compared with a regular diet (CG) on periodontal parameters during a modified experimentally induced gingivitis.

Material and Methods

All participants were asked to refrain from oral hygiene (3 sextant) for 9 days (T1–T2) and were followed for a total of 19 days (T3) while adhering to fasting or a regular diet and resuming oral hygiene. The primary outcome was bleeding on probing in the test sextant (BOP_s), Rustogi plaque index (RPI), gingival crevicular fluid (GCF), blood pressure (BP), body weight (BW), HbA1c and C-reactive protein (CRP) were measured (T1–T3) and ANCOVA and post hoc comparison were applied.

Results

Sixty-six healthy participants were recruited. Forty-three were randomly assigned to TRE (n = 22) and CG (n = 21), while 23 followed BF, avoiding food and drinks during the day. At T2, BF demonstrated significantly less increase in BOP_s, and GCF increased in CG only. Analysis revealed significant differences in change for BOP_s between BF and CG (−9.48% [−17.18; −1.79]) and BF and TRE (−9.19% [−15.07; −3.32]) as well as for GCF between BF and CG (−0.06 μL [−7.22; −0.66]) and TRE and CG (−0.08 μL [−0.17; −0.00]).

Conclusion

This study indicates beneficial effects of different fasting protocols on oral experimental gingivitis and metabolic parameters, but results are limited by randomisation issues and potential bias in the BF group.

Abstract Image

查看原文本刊更多论文

间歇性禁食减少牙龈炎症：一项三组临床试验。

目的：评价宗教bah 'í干断食（BF）或16:8限时饮食（TRE）与常规饮食（CG）对改良实验性牙龈炎患者牙周参数的影响。材料和方法：所有参与者被要求在9天（T1-T2）内避免口腔卫生（3六分仪），并在坚持禁食或正常饮食并恢复口腔卫生的情况下随访19天（T3）。主要观察指标为六分仪探查出血（BOP_s），测量Rustogi斑块指数（RPI）、龈沟液（GCF）、血压（BP）、体重（BW）、糖化血红蛋白（HbA1c）和c反应蛋白（CRP）（T1-T3），应用ANCOVA和事后比较。结果：66名健康参与者被招募。43人被随机分配到TRE组（n = 22）和CG组（n = 21），而23人跟随BF组，白天不吃不喝。在T2时，BF显示BOP_s的增加明显减少，GCF仅在CG时增加。分析显示，BF和CG的BOP_s变化差异显著(-9.48% [-17.18；-1.79])， BF和TRE (-9.19% [-15.07；-3.32])， BF - CG间GCF (-0.06 μL [-7.22；-0.66])， TRE和CG (-0.08 μL [-0.17；-0.00])。结论：本研究表明，不同的禁食方案对口腔实验性牙龈炎和代谢参数有有益的影响，但结果受到随机化问题和BF组潜在偏倚的限制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of Clinical Periodontology 医学-牙科与口腔外科

CiteScore

13.30

自引率

10.40%

发文量

175

审稿时长

3-8 weeks

期刊介绍： Journal of Clinical Periodontology was founded by the British, Dutch, French, German, Scandinavian, and Swiss Societies of Periodontology. The aim of the Journal of Clinical Periodontology is to provide the platform for exchange of scientific and clinical progress in the field of Periodontology and allied disciplines, and to do so at the highest possible level. The Journal also aims to facilitate the application of new scientific knowledge to the daily practice of the concerned disciplines and addresses both practicing clinicians and academics. The Journal is the official publication of the European Federation of Periodontology but wishes to retain its international scope. The Journal publishes original contributions of high scientific merit in the fields of periodontology and implant dentistry. Its scope encompasses the physiology and pathology of the periodontium, the tissue integration of dental implants, the biology and the modulation of periodontal and alveolar bone healing and regeneration, diagnosis, epidemiology, prevention and therapy of periodontal disease, the clinical aspects of tooth replacement with dental implants, and the comprehensive rehabilitation of the periodontal patient. Review articles by experts on new developments in basic and applied periodontal science and associated dental disciplines, advances in periodontal or implant techniques and procedures, and case reports which illustrate important new information are also welcome.