Investigating Human Liver Tissue-Resident Memory T Cells from the Perspectives of Gastroenterologists and Hepatologists.

IF 3.2 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY
Gut and Liver Pub Date : 2025-03-15 Epub Date: 2025-03-10 DOI:10.5009/gnl240366
Ji Won Han, Eui-Cheol Shin
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引用次数: 0

Abstract

Liver tissue-resident memory T (TRM) cells play a pivotal role in hepatic immune responses. Their unique residence within liver sinusoids allow continuous antigen surveillance. In this review, we highlight the role of liver TRM cells in protective immunity and disease pathology. Comparisons between human and murine liver TRM cells reveal species-specific characteristics, suggesting the need for human-focused studies. One key finding is the involvement of liver TRM cells in viral hepatitis, where they can both control infection and contribute to liver damage. Liver TRM cells also exhibit dual roles in metabolic-associated steatotic liver disease, promoting inflammation and fibrosis while also contributing to fibrosis resolution. In autoimmune liver diseases, such as autoimmune hepatitis and primary sclerosing cholangitis, the presence of liver TRM cells correlates with disease severity. In this review, we underscore the importance of liver TRM cells in vaccine development, particularly vaccines against malaria. Future research should focus on the mechanisms governing TRM-cell formation, maintenance, and function, with the aim of supporting their protective roles while mitigating detrimental effects. Advancing our understanding of liver TRM cells will enhance our knowledge of liver immunology and inform novel therapeutic strategies for liver disease management.

Abstract Image

Abstract Image

从胃肠病学家和肝病学家的角度研究人类肝组织驻留记忆T细胞。
肝组织驻留记忆T (TRM)细胞在肝脏免疫应答中起关键作用。它们在肝窦内的独特住所允许持续的抗原监测。本文就肝脏TRM细胞在保护性免疫和疾病病理中的作用作一综述。人类和小鼠肝脏TRM细胞之间的比较揭示了物种特异性特征,表明需要以人类为重点的研究。一个关键的发现是肝脏TRM细胞参与病毒性肝炎,它们既可以控制感染,也可以导致肝损伤。肝脏TRM细胞在代谢相关的脂肪变性肝病中也表现出双重作用,促进炎症和纤维化,同时也有助于纤维化的消退。在自身免疫性肝病中,如自身免疫性肝炎和原发性硬化性胆管炎,肝脏TRM细胞的存在与疾病严重程度相关。在这篇综述中,我们强调肝脏TRM细胞在疫苗开发中的重要性,特别是针对疟疾的疫苗。未来的研究应关注trm细胞形成、维持和功能的机制,以支持其保护作用,同时减轻有害影响。推进我们对肝脏TRM细胞的理解将增强我们对肝脏免疫学的认识,并为肝脏疾病管理提供新的治疗策略。
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来源期刊
Gut and Liver
Gut and Liver 医学-胃肠肝病学
CiteScore
7.50
自引率
8.80%
发文量
119
审稿时长
6-12 weeks
期刊介绍: Gut and Liver is an international journal of gastroenterology, focusing on the gastrointestinal tract, liver, biliary tree, pancreas, motility, and neurogastroenterology. Gut and Liver delivers up-to-date, authoritative papers on both clinical and research-based topics in gastroenterology. The Journal publishes original articles, case reports, brief communications, letters to the editor and invited review articles in the field of gastroenterology. The Journal is operated by internationally renowned editorial boards and designed to provide a global opportunity to promote academic developments in the field of gastroenterology and hepatology. Gut and Liver is jointly owned and operated by 8 affiliated societies in the field of gastroenterology, namely: the Korean Society of Gastroenterology, the Korean Society of Gastrointestinal Endoscopy, the Korean Society of Neurogastroenterology and Motility, the Korean College of Helicobacter and Upper Gastrointestinal Research, the Korean Association for the Study of Intestinal Diseases, the Korean Association for the Study of the Liver, the Korean Pancreatobiliary Association, and the Korean Society of Gastrointestinal Cancer.
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