{"title":"The role of miR-16 and miR-34a family in the regulation of cancers: A review.","authors":"Zahra Sadeghi, Mehrnoush Malekzadeh, Mohammadreza Sharifi, Batool Hashemibeni","doi":"10.1016/j.heliyon.2025.e42733","DOIUrl":null,"url":null,"abstract":"<p><p>microRNAs (miRNAs), regulatory non-coding RNAs, can change translation, and decrease protein expression. miR-16 and miR-34a families are among the most abundant tumor suppressors and highly conserved microRNAs recognized. They have vital regulatory roles in health and disease. Their regulatory functions include biological processes such as improvement, differentiation, cell death, survival, and cell metabolism. The use of miR-16 and miR-34a families as biomarkers for cancer treatment is likely to improve patients with cancer. In this review, we update on recent advances in understanding the mechanism of miR-16 and miR-34 families function in cancer. Knowing about these mechanisms is effective for improving drugs and treatment methods. We also evaluated the reviewed studies and by introducing their weaknesses, we made suggestions for improving future research.</p>","PeriodicalId":12894,"journal":{"name":"Heliyon","volume":"11 4","pages":"e42733"},"PeriodicalIF":3.4000,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11889592/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Heliyon","FirstCategoryId":"103","ListUrlMain":"https://doi.org/10.1016/j.heliyon.2025.e42733","RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/2/28 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"MULTIDISCIPLINARY SCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
microRNAs (miRNAs), regulatory non-coding RNAs, can change translation, and decrease protein expression. miR-16 and miR-34a families are among the most abundant tumor suppressors and highly conserved microRNAs recognized. They have vital regulatory roles in health and disease. Their regulatory functions include biological processes such as improvement, differentiation, cell death, survival, and cell metabolism. The use of miR-16 and miR-34a families as biomarkers for cancer treatment is likely to improve patients with cancer. In this review, we update on recent advances in understanding the mechanism of miR-16 and miR-34 families function in cancer. Knowing about these mechanisms is effective for improving drugs and treatment methods. We also evaluated the reviewed studies and by introducing their weaknesses, we made suggestions for improving future research.
期刊介绍：
Heliyon is an all-science, open access journal that is part of the Cell Press family. Any paper reporting scientifically accurate and valuable research, which adheres to accepted ethical and scientific publishing standards, will be considered for publication. Our growing team of dedicated section editors, along with our in-house team, handle your paper and manage the publication process end-to-end, giving your research the editorial support it deserves.
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