TRTBee: a standalone calculator for time-reinforced toxicity according to European Food Safety Authority honeybee guidelines.

IF 2.8 4区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Environmental Toxicology and Chemistry Pub Date : 2025-06-01 DOI:10.1093/etojnl/vgaf061

Neil Sherborne, Helen M Thompson, Roman Ashauer

引用次数: 0

Abstract

The revised European Food Safety Authority (EFSA) guidance document for the risk assessment of plant protection products on honeybees requires an assessment of time-reinforced toxicity (TRT) using toxicokinetic-toxicodynamic modeling. Although there are user-friendly software options available for this modeling, it is not specialized for this new application; therefore, conducting the TRT assessment still requires additional manual calculations. Here, we present TRTBee, a new, freely available tool that is capable of automatically performing all stages of the TRT assessment. The tool is based on robust and well-known algorithms. We conclude with a brief discussion of the open problems that still exist within the EFSA scheme.

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TRTBee：根据欧洲食品安全局蜜蜂指南的时间增强毒性的独立计算器。

修订后的欧洲食品安全局（EFSA）关于蜜蜂植物保护产品风险评估的指导文件要求使用毒性动力学-毒性动力学模型对时间增强毒性（TRT）进行评估。虽然有用户友好的软件选项可用于此建模，但它不是专门用于此新应用程序的，因此进行TRT评估仍然需要额外的手动计算。在这里，我们提出TRTBee：一个新的，免费提供的工具，能够自动执行所有阶段的TRT评估。该工具基于鲁棒性和众所周知的算法。最后，我们简要讨论了欧洲食品安全局计划中仍然存在的开放性问题。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Environmental Toxicology and Chemistry 环境科学-毒理学

CiteScore

7.40

自引率

9.80%

发文量

265

审稿时长

3.4 months

期刊介绍： The Society of Environmental Toxicology and Chemistry (SETAC) publishes two journals: Environmental Toxicology and Chemistry (ET&C) and Integrated Environmental Assessment and Management (IEAM). Environmental Toxicology and Chemistry is dedicated to furthering scientific knowledge and disseminating information on environmental toxicology and chemistry, including the application of these sciences to risk assessment.[...] Environmental Toxicology and Chemistry is interdisciplinary in scope and integrates the fields of environmental toxicology; environmental, analytical, and molecular chemistry; ecology; physiology; biochemistry; microbiology; genetics; genomics; environmental engineering; chemical, environmental, and biological modeling; epidemiology; and earth sciences. ET&C seeks to publish papers describing original experimental or theoretical work that significantly advances understanding in the area of environmental toxicology, environmental chemistry and hazard/risk assessment. Emphasis is given to papers that enhance capabilities for the prediction, measurement, and assessment of the fate and effects of chemicals in the environment, rather than simply providing additional data. The scientific impact of papers is judged in terms of the breadth and depth of the findings and the expected influence on existing or future scientific practice. Methodological papers must make clear not only how the work differs from existing practice, but the significance of these differences to the field. Site-based research or monitoring must have regional or global implications beyond the particular site, such as evaluating processes, mechanisms, or theory under a natural environmental setting.