Type 2 diabetes mellitus in people with intellectual disabilities: Examining incidence, risk factors, quality of care and related complications. A population-based matched cohort study

IF 6.1 3区医学 Q1 ENDOCRINOLOGY & METABOLISM

Diabetes research and clinical practice Pub Date : 2025-03-07 DOI:10.1016/j.diabres.2025.112090

R. Asaad Baksh , Sarah E. Pape , Li F. Chan , Rory Sheehan , Adam White , Umesh Chauhan , Martin C. Gulliford , André Strydom

{"title":"Type 2 diabetes mellitus in people with intellectual disabilities: Examining incidence, risk factors, quality of care and related complications. A population-based matched cohort study","authors":"R. Asaad Baksh , Sarah E. Pape , Li F. Chan , Rory Sheehan , Adam White , Umesh Chauhan , Martin C. Gulliford , André Strydom","doi":"10.1016/j.diabres.2025.112090","DOIUrl":null,"url":null,"abstract":"<div><h3>Aims</h3><div>People with intellectual disabilities are at higher risk of type 2 diabetes mellitus (T2DM) but there are currently gaps in our understanding related to risk of new onset, care of T2DM and complications.</div></div><div><h3>Methods</h3><div>We examined electronic health-record data from Jan 2010 to May 2022 in 189,172 people with intellectual disabilities and 306,697 age, sex and family practice matched controls. We estimated incidence rates per 1,000-person-years, incidence rate ratios (IRRs), risk factors for T2DM (odds ratio, OR), indicators of quality of care and complications (hazard ratio, HR).</div></div><div><h3>Results</h3><div>Incidence of T2DM in people with intellectual disabilities was 3.74 compared to 2.21 per 1,000 person-years in controls. After allowing for the younger age of T2DM onset in intellectual disabilities, the adjusted IRR was 6.91 (95 % CI 5.81–8.22). Impaired mobility was associated with T2DM incidence in people with intellectual disabilities (OR = 7.72, 5.87–10.15). People with intellectual disabilities received blood tests for HbA1c and cholesterol, and eye and foot examinations less often; and had a 12 % higher risk of developing macrovascular complications.</div></div><div><h3>Conclusions</h3><div>People with intellectual disabilities are at increased risk of T2DM at younger ages, have specific risk factors, experience inequities in care and are at risk for macrovascular complications.</div></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":"222 ","pages":"Article 112090"},"PeriodicalIF":6.1000,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Diabetes research and clinical practice","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0168822725001044","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}

引用次数: 0

Abstract

Aims

People with intellectual disabilities are at higher risk of type 2 diabetes mellitus (T2DM) but there are currently gaps in our understanding related to risk of new onset, care of T2DM and complications.

Methods

We examined electronic health-record data from Jan 2010 to May 2022 in 189,172 people with intellectual disabilities and 306,697 age, sex and family practice matched controls. We estimated incidence rates per 1,000-person-years, incidence rate ratios (IRRs), risk factors for T2DM (odds ratio, OR), indicators of quality of care and complications (hazard ratio, HR).

Results

Incidence of T2DM in people with intellectual disabilities was 3.74 compared to 2.21 per 1,000 person-years in controls. After allowing for the younger age of T2DM onset in intellectual disabilities, the adjusted IRR was 6.91 (95 % CI 5.81–8.22). Impaired mobility was associated with T2DM incidence in people with intellectual disabilities (OR = 7.72, 5.87–10.15). People with intellectual disabilities received blood tests for HbA1c and cholesterol, and eye and foot examinations less often; and had a 12 % higher risk of developing macrovascular complications.

Conclusions

People with intellectual disabilities are at increased risk of T2DM at younger ages, have specific risk factors, experience inequities in care and are at risk for macrovascular complications.

查看原文本刊更多论文

求助全文

约1分钟内获得全文求助全文

来源期刊

Diabetes research and clinical practice 医学-内分泌学与代谢

CiteScore

10.30

自引率

3.90%

发文量

862

审稿时长

32 days

期刊介绍： Diabetes Research and Clinical Practice is an international journal for health-care providers and clinically oriented researchers that publishes high-quality original research articles and expert reviews in diabetes and related areas. The role of the journal is to provide a venue for dissemination of knowledge and discussion of topics related to diabetes clinical research and patient care. Topics of focus include translational science, genetics, immunology, nutrition, psychosocial research, epidemiology, prevention, socio-economic research, complications, new treatments, technologies and therapy.