Anti-Neuroinflammatory Labdane Diterpenoids From the Rhizomes of Alpinia zerumbet.

IF 2.3 3区化学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Chemistry & Biodiversity Pub Date : 2025-03-10 DOI:10.1002/cbdv.202500154

Jinghui Wu, Wenxin Zhang, Jingwen Xu, Yihai Wang, Xiangjiu He

引用次数: 0

Abstract

Alpinia zerumbet, commonly known as shell ginger, is a plant of significant ornamental and medicinal value. In the present study, nine labdane-type diterpenoids, including four novel (1-4) and five known (5-9), were isolated and identified from the rhizomes of A. zerumbet. Anti-neuroinflammatory activities of the isolated labdane-type diterpenoids were evaluated in lipopolysaccharide (LPS)-stimulated microglia BV2 cells. Compounds 3, 5, 6, and 8 could significantly inhibit the production of nitric oxide (NO) in LPS-stimulated BV2 cells. Among them, the IC₅₀ values of compounds 5 and 8 were 26.14 ± 1.62 and 17.29 ± 6.28 µM, which were lower than that of the positive control, minocycline (IC₅₀ = 30.26 ± 1.99 µM).

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来源期刊

Chemistry & Biodiversity 环境科学-化学综合

CiteScore

3.40

自引率

10.30%

发文量

475

审稿时长

2.6 months

期刊介绍： Chemistry & Biodiversity serves as a high-quality publishing forum covering a wide range of biorelevant topics for a truly international audience. This journal publishes both field-specific and interdisciplinary contributions on all aspects of biologically relevant chemistry research in the form of full-length original papers, short communications, invited reviews, and commentaries. It covers all research fields straddling the border between the chemical and biological sciences, with the ultimate goal of broadening our understanding of how nature works at a molecular level. Since 2017, Chemistry & Biodiversity is published in an online-only format.