Development and Preliminary Validation of Standardized Regression-Based Change Scores as Measures of Transitional Cognitive Decline.

IF 2.1 4区心理学 Q2 PSYCHOLOGY

Archives of Clinical Neuropsychology Pub Date : 2025-03-10 DOI:10.1093/arclin/acaf015

Andrew M Kiselica, Alyssa N Kaser, Troy A Webber, Brent J Small, Jared F Benge

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引用次数: 0

Abstract

Objective: An increasing focus in Alzheimer's disease and aging research is to identify transitional cognitive decline. One means of indexing change over time in serial cognitive evaluations is to calculate standardized regression-based (SRB) change indices. This paper includes development and preliminary validation of SRB indices for the Uniform Data Set 3.0 Neuropsychological Battery, as well as base rate data to aid in their interpretation.

Method: The sample included 1341 cognitively intact older adults with serial assessments over 0.5-2 years in the National Alzheimer's Coordinating Center Database. SRB change scores were calculated in half of the sample, then validated in the other half of the sample. Base rates of SRB decline were evaluated at z-score cut-points, corresponding to two-tailed p-values of .20 (z = -1.282), 0.10 (z = -1.645) and .05 (z = -1.96). We examined convergent associations of SRB indices for each cognitive measure with each other, as well as concurrent associations of SRB indices with Clinical Dementia Rating sum of box scores (CDR-SB).

Results: SRB equations were able to significantly predict the selected cognitive variables. The base rate of at least one significant SRB decline across the entire battery ranged from 28.91% to 64.90%. SRB indices for cognitive measures demonstrated theoretically expected significant positive associations with each other. Additionally, CDR-SB impairment was associated with decline on three different SRB indices.

Conclusions: This paper provides preliminary validation of SRB indices in a large sample, and we present a user-friendly tool for calculating SRB values.

查看原文本刊更多论文

基于标准化回归的变化评分作为过渡性认知衰退的测量方法的发展和初步验证。

目的：识别过渡性认知衰退是阿尔茨海默病和衰老研究日益关注的焦点。序列认知评价中随时间变化的索引方法之一是计算基于标准化回归的变化指数。本文包括统一数据集3.0神经心理学电池的SRB指数的开发和初步验证，以及基础率数据，以帮助他们的解释。方法：样本包括1341名认知完整的老年人，在国家阿尔茨海默病协调中心数据库中进行了超过0.5-2年的系列评估。在一半的样本中计算SRB变化分数，然后在另一半样本中验证。SRB下降的基本比率在z-score切割点进行评估，对应于双尾p值为0.20 (z = -1.282), 0.10 （z = -1.645）和0.05 （z = -1.96）。我们检验了每个认知测量的SRB指数彼此之间的趋同关联，以及SRB指数与临床痴呆评分框评分之和（CDR-SB）的并发关联。结果：SRB方程能显著预测所选认知变量。在整个电池中，至少一次显著SRB下降的基本率在28.91%到64.90%之间。SRB指数在认知测量中表现出理论预期的显著正相关。此外，CDR-SB损伤与三个不同SRB指数的下降有关。结论：本文在大样本中对SRB指标进行了初步验证，并提出了一种用户友好的计算SRB值的工具。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Archives of Clinical Neuropsychology 医学-心理学

CiteScore

4.60

自引率

7.70%

发文量

358

审稿时长

6-12 weeks

期刊介绍： The journal publishes original contributions dealing with psychological aspects of the etiology, diagnosis, and treatment of disorders arising out of dysfunction of the central nervous system. Archives of Clinical Neuropsychology will also consider manuscripts involving the established principles of the profession of neuropsychology: (a) delivery and evaluation of services, (b) ethical and legal issues, and (c) approaches to education and training. Preference will be given to empirical reports and key reviews. Brief research reports, case studies, and commentaries on published articles (not exceeding two printed pages) will also be considered. At the discretion of the editor, rebuttals to commentaries may be invited. Occasional papers of a theoretical nature will be considered.