Association between Serum Uric Acid Levels and Islet Beta-cell Function in Type 2 Diabetes Mellitus.

IF 0.6 Q3 MEDICINE, GENERAL & INTERNAL

Annals of African Medicine Pub Date : 2025-04-01 Epub Date: 2025-03-10 DOI:10.4103/aam.aam_190_24

Nitesh Shukla, Ashok Kumar, Lalit Kumar Tyagi, K P Sindhura

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引用次数: 0

Abstract

Background: Type 2 diabetes mellitus (T2DM) is a disease characterized by insulin resistance (IR) and insufficiency. Serum uric acid (SUA) is a biomarker of diabetes risk, with Indian populations having varying levels due to diet, lifestyle, and genetic susceptibility. However, the relationship between UA and T2DM is contentious due to its association with obesity. The study explores the relationship between serum uric acid levels and islet beta-cell function in type 2 diabetes patients, estimating the correlation, examining factors such as age, gender, or body mass index (BMI), and estimating the correlation between uric acid levels and IR.

Methods: A study at Santosh Medical College in Ghaziabad involved 167 patients over 18 years old with type 2 diabetes, diagnosed based on fasting plasma glucose levels, and glycated hemoglobin (HbA1c). The patients underwent detailed history and physical examination, including fasting blood glucose, lipid profile, serum urea, creatinine, uric acid, HbA1c, insulin sensitivity index, and islet beta-cell function indices.

Results: The study involved 170 patients, with 84 (49.41%) being male and 86 (50.59%) being female. The mean lipid profile was similar across genders, with no significant differences in HbA1c, random blood sugar (RBS), total cholesterol (TC), triglyceride (TG), high-density lipoprotein-cholesterol (HDL-c), and homeostatic model assessment of IR (HOMA-IR). Smoking and alcohol consumption were significantly higher in males, while family history of T2DM was comparable between both genders. The relationship between SUA quartiles and other parameters and HOMA-IR in males was not significantly different, while in females, the mean age, BMI, waist circumference, waist-hip ratio, HbA1c, RBS, TC, TG, HDL-c, low-density lipoprotein-cholesterol, HOMA-IR, and creatinine were not significantly different. The correlation of HOMA-IR and uric acid was positive but not significantly associated.

Conclusion: The study found a significant positive correlation between serum uric acid levels and IR in males and females and a positive but nonsignificant correlation with BMI, suggesting that SUA could predict islet β-cell activity.

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2型糖尿病患者血清尿酸水平与胰岛β细胞功能的关系

背景：2型糖尿病（T2DM）是一种以胰岛素抵抗（IR）和功能不全为特征的疾病。血清尿酸（SUA）是糖尿病风险的生物标志物，由于饮食、生活方式和遗传易感性，印度人群的尿酸水平各不相同。然而，UA与2型糖尿病之间的关系存在争议，因为它与肥胖有关。该研究探讨了2型糖尿病患者血清尿酸水平与胰岛β细胞功能之间的关系，估计了相关性，检查了年龄、性别或体重指数（BMI）等因素，并估计了尿酸水平与IR之间的相关性。方法：Ghaziabad Santosh医学院的一项研究纳入了167名18岁以上的2型糖尿病患者，根据空腹血糖水平和糖化血红蛋白（HbA1c）进行诊断。对患者进行详细的病史和体格检查，包括空腹血糖、血脂、血清尿素、肌酐、尿酸、糖化血红蛋白、胰岛素敏感性指数、胰岛β细胞功能指数。结果：共纳入170例患者，其中男性84例（49.41%），女性86例（50.59%）。平均脂质分布在性别之间相似，HbA1c、随机血糖（RBS）、总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白-胆固醇（HDL-c）和稳态IR模型评估（HOMA-IR）无显著差异。男性吸烟和饮酒明显高于男性，而两种性别之间的2型糖尿病家族史具有可比性。男性SUA四分位数等参数与HOMA-IR的关系无显著性差异，女性平均年龄、BMI、腰围、腰臀比、HbA1c、RBS、TC、TG、HDL-c、低密度脂蛋白胆固醇、HOMA-IR、肌酐的关系无显著性差异。HOMA-IR与尿酸呈正相关，但相关性不显著。结论：本研究发现男性和女性血清尿酸水平与IR呈显著正相关，与BMI呈显著正相关，提示SUA可预测胰岛β细胞活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of African Medicine MEDICINE, GENERAL & INTERNAL-

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0.90

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0.00%

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期刊介绍： The Annals of African Medicine is published by the Usmanu Danfodiyo University Teaching Hospital, Sokoto, Nigeria and the Annals of African Medicine Society. The Journal is intended to serve as a medium for the publication of research findings in the broad field of Medicine in Africa and other developing countries, and elsewhere which have relevance to Africa. It will serve as a source of information on the state of the art of Medicine in Africa, for continuing education for doctors in Africa and other developing countries, and also for the publication of meetings and conferences. The journal will publish articles I any field of Medicine and other fields which have relevance or implications for Medicine.