Association Between Visceral Fat Metabolism Score and Cataract Risk in US Adults: National Health and Nutrition Examination Survey 1999 to 2008

IF 4.1 1区医学 Q1 OPHTHALMOLOGY

American Journal of Ophthalmology Pub Date : 2025-03-08 DOI:10.1016/j.ajo.2025.03.010

Wen Guo , Hongfei Xue , Qing Li , Zimu Wen , Zhihuan Zhou , Yujun Dong , Meiqin He , Yankai Li , Fangfei Li , Yi Tong

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引用次数: 0

Abstract

PURPOSE

The present work focused on investigating the relation of visceral fat metabolic score (METS-VF) with cataract prevalence among the American adults.

DESIGN

A cross-sectional study.

METHODS

This cross-sectional study, based on the U.S. population, used data from the National Health and Nutrition Examination Survey (NHANES) conducted between 1999 and 2008. For assessing the association of METS-VF with cataract, we employed multivariable logistic regression analysis, subgroup analyses, and restricted cubic splines (RCS) analysis for exploring their relation. Additionally, receiver operating characteristic (ROC) curve analysis was conducted to compare the cataract diagnostic abilities of METS-VF, body mass index (BMI), waist circumference (WC), and waist-to-height ratio (WHtR).

RESULTS

There were altogether 2,730 participants included, of whom 290 had cataract.METS-VF was significantly related to cataract (P < .001). As METS-VF quartiles increased, cataract prevalence also increased (Q1: 1.90%, Q2: 6.74%, Q3: 10.25%, Q4: 23.61%). After adjusting for all variables, METS-VF still showed positive relation to cataract prevalence (odds ratio (OR) = 3.14, 95% confidence interval (CI): 1.67, 5.93). Subgroup analysis revealed a consistent relationship between METS-VF and cataracts across different groups. The RCS results showed that there was no significant nonlinear relationship between METS-VF and cataracts (P−non−linear = 0.209). ROC curve analysis showed that METS-VF outperformed BMI, WC, and WHtR in cataract prediction.

CONCLUSION

METS-VF is significantly positively related to a higher cataract prevalence, and this relationship remains robust across various subgroups. Additionally, METS-VF demonstrates a stronger predictive ability for cataract than BMI, WC, and WHtR.

查看原文本刊更多论文

目的：本研究主要调查美国成年人内脏脂肪代谢得分（METS-VF）与白内障患病率的关系：方法：横断面研究：这项横断面研究基于美国人口，使用的数据来自 1999 年至 2008 年间进行的美国国家健康与营养调查（NHANES）。为了评估 METS-VF 与白内障的关系，我们采用了多变量逻辑回归分析、亚组分析和限制性立方样条（RCS）分析来探讨两者之间的关系。此外，我们还进行了接收器操作特征曲线（ROC）分析，以比较 METS-VF、体重指数（BMI）、腰围（WC）和腰围身高比（WHtR）对白内障的诊断能力：METS-VF与白内障有显著相关性（P < 0.001）。随着 METS-VF 四分位数的增加，白内障患病率也随之增加（Q1：1.90%；Q2：6.74%；Q3：10.25%；Q4：23.61%）。对所有变量进行调整后，METS-VF 仍与白内障患病率呈正相关（几率比（OR）= 3.14，95% 置信区间（CI）：1.67，5.93）。亚组分析显示，METS-VF 与白内障之间的关系在不同组别中是一致的。RCS 结果显示，METS-VF 与白内障之间不存在显著的非线性关系（P-非线性 = 0.209）。ROC 曲线分析表明，在预测白内障方面，METS-VF 优于 BMI、WC 和 WHtR：结论：METS-VF 与较高的白内障患病率呈显著正相关，而且这种关系在不同的亚组中都保持稳定。此外，METS-VF 对白内障的预测能力强于 BMI、WC 和 WHtR。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American Journal of Ophthalmology 医学-眼科学

CiteScore

9.20

自引率

7.10%

发文量

406

审稿时长

36 days

期刊介绍： The American Journal of Ophthalmology is a peer-reviewed, scientific publication that welcomes the submission of original, previously unpublished manuscripts directed to ophthalmologists and visual science specialists describing clinical investigations, clinical observations, and clinically relevant laboratory investigations. Published monthly since 1884, the full text of the American Journal of Ophthalmology and supplementary material are also presented online at www.AJO.com and on ScienceDirect. The American Journal of Ophthalmology publishes Full-Length Articles, Perspectives, Editorials, Correspondences, Books Reports and Announcements. Brief Reports and Case Reports are no longer published. We recommend submitting Brief Reports and Case Reports to our companion publication, the American Journal of Ophthalmology Case Reports. Manuscripts are accepted with the understanding that they have not been and will not be published elsewhere substantially in any format, and that there are no ethical problems with the content or data collection. Authors may be requested to produce the data upon which the manuscript is based and to answer expeditiously any questions about the manuscript or its authors.