{"title":"Heme Unleashed: NLRP12 Orchestrates PANoptosis in a Symphony of Cell Fate.","authors":"Naomi Navuluri, Vinod Kumar Yata, Sudharshan Reddy Dachani, Kartik Rachakonda, Narasaiah Kolliputi","doi":"10.1007/s12013-025-01712-7","DOIUrl":null,"url":null,"abstract":"<p><p>Pattern recognition receptors (PRRs) help protect hosts from pathogens in different ways. They bind to pathogen-associated molecular patterns (PAMPs), damage-associated molecular patterns (DAMPs), or other homeostatic irregularities caused by these patterns to activate an immune response against a pathogen. Certain PRRs activate inflammasomes, leading to cell death and the formation of PANoptosomes, a key process in PANoptosis. PRRs help protect against pathogens, however an excessive number can cause harm to the body and even death. The mechanisms of how to control the PRRs remain unknown. Sundaram et al. [1] address this gap by investigating pathways that activate PANoptosomes in infection-mimicking conditions. They found that the sensor NLRP12 activated PANoptosomes causes inflammation in response to infections leading to the hypothesis that targeting the sensor NLRP12 could be a means to stop the harmful effects of excessive PRRs.This discovery suggests that targeting NLRP12 could mitigate the harmful effects of PRR overactivation, offering a potential therapeutic avenue.</p>","PeriodicalId":510,"journal":{"name":"Cell Biochemistry and Biophysics","volume":" ","pages":""},"PeriodicalIF":1.8000,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cell Biochemistry and Biophysics","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1007/s12013-025-01712-7","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Pattern recognition receptors (PRRs) help protect hosts from pathogens in different ways. They bind to pathogen-associated molecular patterns (PAMPs), damage-associated molecular patterns (DAMPs), or other homeostatic irregularities caused by these patterns to activate an immune response against a pathogen. Certain PRRs activate inflammasomes, leading to cell death and the formation of PANoptosomes, a key process in PANoptosis. PRRs help protect against pathogens, however an excessive number can cause harm to the body and even death. The mechanisms of how to control the PRRs remain unknown. Sundaram et al. [1] address this gap by investigating pathways that activate PANoptosomes in infection-mimicking conditions. They found that the sensor NLRP12 activated PANoptosomes causes inflammation in response to infections leading to the hypothesis that targeting the sensor NLRP12 could be a means to stop the harmful effects of excessive PRRs.This discovery suggests that targeting NLRP12 could mitigate the harmful effects of PRR overactivation, offering a potential therapeutic avenue.
期刊介绍:
Cell Biochemistry and Biophysics (CBB) aims to publish papers on the nature of the biochemical and biophysical mechanisms underlying the structure, control and function of cellular systems
The reports should be within the framework of modern biochemistry and chemistry, biophysics and cell physiology, physics and engineering, molecular and structural biology. The relationship between molecular structure and function under investigation is emphasized.
Examples of subject areas that CBB publishes are:
· biochemical and biophysical aspects of cell structure and function;
· interactions of cells and their molecular/macromolecular constituents;
· innovative developments in genetic and biomolecular engineering;
· computer-based analysis of tissues, cells, cell networks, organelles, and molecular/macromolecular assemblies;
· photometric, spectroscopic, microscopic, mechanical, and electrical methodologies/techniques in analytical cytology, cytometry and innovative instrument design
For articles that focus on computational aspects, authors should be clear about which docking and molecular dynamics algorithms or software packages are being used as well as details on the system parameterization, simulations conditions etc. In addition, docking calculations (virtual screening, QSAR, etc.) should be validated either by experimental studies or one or more reliable theoretical cross-validation methods.