ESIPT-driven imaging: a thiazole probe for lipid droplets and plasma membranes†

Abstract

Fluorescence imaging allows high-resolution visualization of cellular processes. This study introduces a novel ESIPT probe with dual localization for lipid droplets and plasma membranes. Initially, the blue channel imaging reveals the probe's affinity for the plasma membrane, and then it redistributes into lipid droplets, showcasing its strong affinity for the hydrophobic lipid core.