Intercalation of Neutral Guests in Pillared Salt Cocrystals of 5-Ureidosalyclic Acid.

IF 3.2 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Crystal Growth & Design Pub Date : 2025-02-20 eCollection Date: 2025-03-05 DOI:10.1021/acs.cgd.4c01715

Stuart R Kennedy, Toby J Blundell, Elizabeth F Henderson, Adeline P Miquelot, Jonathan W Steed

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引用次数: 0

Abstract

The salts of 5-ureidosalyclic acid (5-USA) form a range of pillared salt inclusion complexes from basic solvents, namely, triethylamine, piperidine, morpholine, and 4-ethylpyridine. The triethylamine derivative is unsolvated, while the other salts include 1-3 solvent molecules of formula XH⁺(5-USA-H)^-·nX (X = morpholine, n = 1, 2, and 3 (2a - 2c); X = 4-ethylpyridine, n = 1 (3) and X = piperidine, n = 2.5 (4)). The morpholine salt expands the layered structure to include 1, 2, or 3 guests. The 5-USA anion can also act as a bidentate ligand for manganese(III), again forming highly solvated inclusion complex anions [Mn(5-USA-H)₂(Solv)₂]^-. When interacting strongly with the countercation, the 5-USA anions adopt an unusual cis carboxylate isomer form, whereas the morpholinium salt solvate (H-morpholine)[Mn(5-USA-H)₂(morpholine)₂]·2(morpholine) (5c) is trans. The soft, plastic crystals of this complex gradually desolvate, losing channel morpholine and ultimately spontaneously recrystallizing as the 5-USA salt dimorpholine inclusion complex 2b. The complex hydrogen-bonded, pillared 5-USA salts illustrate a design concept for intercalated materials of forming charged, planar layers that leave the charge-balancing counterion exposed, such that interlayer guest species must be incorporated to effectively solvate the charged moieties.

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来源期刊

Crystal Growth & Design 化学-材料科学：综合

CiteScore

6.30

自引率

10.50%

发文量

650

审稿时长

1.9 months

期刊介绍： The aim of Crystal Growth & Design is to stimulate crossfertilization of knowledge among scientists and engineers working in the fields of crystal growth, crystal engineering, and the industrial application of crystalline materials. Crystal Growth & Design publishes theoretical and experimental studies of the physical, chemical, and biological phenomena and processes related to the design, growth, and application of crystalline materials. Synergistic approaches originating from different disciplines and technologies and integrating the fields of crystal growth, crystal engineering, intermolecular interactions, and industrial application are encouraged.