{"title":"Engineering fluorescent carbon dot sensor with rare earth europium for the detection of uranium (VI) ion in vivo","authors":"Xiayu Zhou, Yue Wang, Jiayi Song, Lihao Xiong, Xin Zhao, Sihan Chen, Weichao Zhao, Le Li, Deshuai Zhen","doi":"10.1007/s00604-025-07078-0","DOIUrl":null,"url":null,"abstract":"<div><p>Three types of carbon dots were synthesized using the same precursor (folic acid and europium nitrate) via different preparation methods (doping and direct coordination). A comprehensive comparison and analysis of the morphology, surface groups, and optical properties of the prepared carbon dots (CD), europium-doped carbon dots (CD-Eu), and europium-functionalized carbon dots (CD@Eu) were conducted. Moreover, due to the higher quantum yield, excellent stability, and outstanding selectivity for UO<sub>2</sub><sup>2+</sup> exhibited by CD-Eu, we selected CD-Eu as the probe for subsequent applications. CD-Eu showed a sensitive response to UO<sub>2</sub><sup>2+</sup> within the concentration range 25 ~ 200 nM, with a detection limit of 0.84 nM (0.42 μg·L<sup>−1</sup>). Additionally, CD-Eu demonstrated excellent accuracy and recovery in spiked detection of real water samples. Furthermore, we discovered that this probe could detect UO<sub>2</sub><sup>2+</sup> both <i>in</i> <i>vitro</i> and <i>in</i> <i>viv</i>o. This strategy provides a promising fluorescent sensor for the detection of UO<sub>2</sub><sup>2+</sup> in water and biological samples, holding significant implications for addressing UO<sub>2</sub><sup>2+</sup> contamination issues.</p><h3>Graphical abstract</h3>\n<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"192 4","pages":""},"PeriodicalIF":5.3000,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Microchimica Acta","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s00604-025-07078-0","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, ANALYTICAL","Score":null,"Total":0}
引用次数: 0
Abstract
Three types of carbon dots were synthesized using the same precursor (folic acid and europium nitrate) via different preparation methods (doping and direct coordination). A comprehensive comparison and analysis of the morphology, surface groups, and optical properties of the prepared carbon dots (CD), europium-doped carbon dots (CD-Eu), and europium-functionalized carbon dots (CD@Eu) were conducted. Moreover, due to the higher quantum yield, excellent stability, and outstanding selectivity for UO22+ exhibited by CD-Eu, we selected CD-Eu as the probe for subsequent applications. CD-Eu showed a sensitive response to UO22+ within the concentration range 25 ~ 200 nM, with a detection limit of 0.84 nM (0.42 μg·L−1). Additionally, CD-Eu demonstrated excellent accuracy and recovery in spiked detection of real water samples. Furthermore, we discovered that this probe could detect UO22+ both invitro and invivo. This strategy provides a promising fluorescent sensor for the detection of UO22+ in water and biological samples, holding significant implications for addressing UO22+ contamination issues.
期刊介绍：
As a peer-reviewed journal for analytical sciences and technologies on the micro- and nanoscale, Microchimica Acta has established itself as a premier forum for truly novel approaches in chemical and biochemical analysis. Coverage includes methods and devices that provide expedient solutions to the most contemporary demands in this area. Examples are point-of-care technologies, wearable (bio)sensors, in-vivo-monitoring, micro/nanomotors and materials based on synthetic biology as well as biomedical imaging and targeting.
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