Fabrication of a Whitlockite/PLGA Scaffold with Hierarchical Porosity for Bone Repair

IF 9.6 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Letters Pub Date : 2025-03-10 DOI:10.1021/acs.nanolett.4c06487

Caifeng Wang, Ruofei Zhang, Ki-Jae Jeong, Wei Xiong, Zongran Liu, Zhengya Xie, Lin Hou, Jianxiao Gong, Zheng Lian, Mali Zu, Kelong Fan, Tianjiao Ji

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引用次数: 0

Abstract

Regenerating functional bone tissue in critical-sized defects remains a formidable issue. Bone-tissue engineering (BTE) scaffolds are emerging as potential alternatives to bone transplantation for the repair of bone defects. However, developing BTE scaffolds with unique bone-healing properties and natural bone porous structure is challenging. Herein, we presented a biomimetic scaffold with hierarchical porosity via a solvent casting/particulate leaching method. The scaffold comprises osteoinductive whitlockite (WH) nanoparticles evenly dispersed in a poly(lactic-co-glycolic acid) (PLGA) matrix. Highly interconnected pores with hierarchical variations are present in the scaffold, enabling superior solution diffusion and compressive strength. Notably, the WH/PLGA scaffold effectively promoted osteoblast differentiation in vitro and induced bone formation in rat tibia defects, surpassing the performance of both the hydroxyapatite (HAP)/PLGA scaffold and the PLGA scaffold. This study provides a low-cost, facile, and scalable strategy for fabricating BTE scaffolds with favorable mechanical properties, biocompatibility, and bone repair capability.

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来源期刊

Nano Letters 工程技术-材料科学：综合

CiteScore

16.80

自引率

2.80%

发文量

1182

审稿时长

1.4 months

期刊介绍： Nano Letters serves as a dynamic platform for promptly disseminating original results in fundamental, applied, and emerging research across all facets of nanoscience and nanotechnology. A pivotal criterion for inclusion within Nano Letters is the convergence of at least two different areas or disciplines, ensuring a rich interdisciplinary scope. The journal is dedicated to fostering exploration in diverse areas, including: - Experimental and theoretical findings on physical, chemical, and biological phenomena at the nanoscale - Synthesis, characterization, and processing of organic, inorganic, polymer, and hybrid nanomaterials through physical, chemical, and biological methodologies - Modeling and simulation of synthetic, assembly, and interaction processes - Realization of integrated nanostructures and nano-engineered devices exhibiting advanced performance - Applications of nanoscale materials in living and environmental systems Nano Letters is committed to advancing and showcasing groundbreaking research that intersects various domains, fostering innovation and collaboration in the ever-evolving field of nanoscience and nanotechnology.