The long-term impact of hypertriglyceridemia-waist phenotype on major adverse cardiovascular events in elderly patients with OSA.

IF 2 4区医学 Q3 CLINICAL NEUROLOGY

Sleep and Breathing Pub Date : 2025-03-08 DOI:10.1007/s11325-025-03257-8

Tian-Jiao Li, Qiao Feng, Ting-Yu Nie, Ying-Hui Gao, Ling Yang, Li-Bo Zhao, Xin Xue, Zhe Zhao, Wei-Meng Cai, Dong Rui, Ji-Ming Han, Lin Liu

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引用次数: 0

Abstract

Introduction: The hypertriglyceridemia-waist (HTGW) phenotype is a prevalent risk factor for cardiovascular diseases and obstructive sleep apnea (OSA). However, the impactof the HTGW phenotype on the simultaneous occurrence of OSA and cardiovascular diseases remains unexplored. This study aimed to determine whether the HTGW phenotype elevates the incidence of major adverse cardiovascular events (MACE) in patients with OSA, such as hospitalization for unstable angina and heart failure, myocardial infarction, and cardiovascular death, in patients with OSA.

Methods: A total of 1,290 patients with OSA were recruited from six hospitals for follow-up. According to the Chinese population criteria recommended by the International Diabetes Federation, the patients were divided into four groups: normal triglyceride waist circumference (NTNW) phenotype, pure high triglyceride (HTNW) phenotype, pure high waist circumference (NTGW) phenotype, and HTGW phenotype. The prognosis for MACE was evaluated using Cox proportional hazards analysis. The prognosis of MACE was evaluated using Cox proportional hazards analysis.

Results: 207 (17.9%) developed an HTGW phenotype. After a median of 42 months of follow-up, 119 (10.3%) experienced MACE. Cox proportional hazards analysis revealed that patients exhibiting the HTGW phenotype had a 1.963-fold higher risk of developing MACE than patients with the NTNW phenotype (P = 0.012). These results remained significant after adjusting for confounders, and a 2.186-fold increased risk of MACE was found in patients with NTGW phenotype (P = 0.012). Subgroup analyses revealed an increased risk of MACE in OSA patients with HTGW phenotype and NTGW phenotype that were older than or equal to 70 years, male, and had moderate-to-severe OSA (all P-values < 0.05).

Conclusion: The HTGW and NTGW phenotypes significantly increase MACE risk among elderly patients with OSA.

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高甘油三酯血症-腰型对老年OSA患者主要不良心血管事件的长期影响

高甘油三酯血症-腰（HTGW）表型是心血管疾病和阻塞性睡眠呼吸暂停（OSA）的普遍危险因素。然而，HTGW表型对OSA和心血管疾病同时发生的影响尚不清楚。本研究旨在确定HTGW表型是否会增加OSA患者主要不良心血管事件（MACE）的发生率，如OSA患者因不稳定心绞痛和心力衰竭住院、心肌梗死和心血管性死亡。方法：从6家医院招募1290例OSA患者进行随访。根据国际糖尿病联合会推荐的中国人群标准，将患者分为正常甘油三酯腰围（NTNW）表型、纯高甘油三酯（HTNW）表型、纯高腰围（NTGW）表型和HTGW表型四组。采用Cox比例风险分析评价MACE的预后。采用Cox比例风险分析评价MACE的预后。结果：207例（17.9%）出现HTGW表型。中位随访42个月后，119例（10.3%）出现MACE。Cox比例风险分析显示，HTGW表型患者发生MACE的风险是NTNW表型患者的1.963倍（P = 0.012）。在调整混杂因素后，这些结果仍然显着，NTGW表型患者MACE风险增加2.186倍（P = 0.012）。亚组分析显示，年龄≥70岁、男性、中重度OSA的HTGW和NTGW表型OSA患者MACE风险增加（p值均为p值）。结论：HTGW和NTGW表型显著增加老年OSA患者MACE风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Sleep and Breathing 医学-呼吸系统

CiteScore

5.20

自引率

4.00%

发文量

222

审稿时长

3-8 weeks

期刊介绍： The journal Sleep and Breathing aims to reflect the state of the art in the international science and practice of sleep medicine. The journal is based on the recognition that management of sleep disorders requires a multi-disciplinary approach and diverse perspectives. The initial focus of Sleep and Breathing is on timely and original studies that collect, intervene, or otherwise inform all clinicians and scientists in medicine, dentistry and oral surgery, otolaryngology, and epidemiology on the management of the upper airway during sleep. Furthermore, Sleep and Breathing endeavors to bring readers cutting edge information about all evolving aspects of common sleep disorders or disruptions, such as insomnia and shift work. The journal includes not only patient studies, but also studies that emphasize the principles of physiology and pathophysiology or illustrate potentially novel approaches to diagnosis and treatment. In addition, the journal features articles that describe patient-oriented and cost-benefit health outcomes research. Thus, with peer review by an international Editorial Board and prompt English-language publication, Sleep and Breathing provides rapid dissemination of clinical and clinically related scientific information. But it also does more: it is dedicated to making the most important developments in sleep disordered breathing easily accessible to clinicians who are treating sleep apnea by presenting well-chosen, well-written, and highly organized information that is useful for patient care.