The association between occupational lead exposure and serum levels of vitamin D3 and a bone turnover biomarker in smelter workers.

IF 2.6 3区医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

International Archives of Occupational and Environmental Health Pub Date : 2025-03-08 DOI:10.1007/s00420-025-02125-y

Rateba Said Mohammed, Basma Hussein Mourad

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引用次数: 0

Abstract

Objective: Bone tissue is the chief target for lead (Pb) in chronic exposure. This study aimed to demonstrate the relation between the blood lead levels (BLL) and serum levels of 1,25 dihydroxy cholecalciferol (vitamin D3) and type I collagen cross-linked C-telopeptide (CTX-1) as a biomarker of bone turnover among some Egyptian workers occupationally exposed to Pb in the smelting process. The study also targeted to identify any clinical manifestations indicative of skeletal system affection and their association with the performed investigations.

Methods: A total of 48 smelter workers and 48 administrative controls participated in the study. All subjects underwent comprehensive medical and occupational history taking and detailed clinical examinations, with a particular focus on symptoms indicative of skeletal system involvement. These symptoms included generalized bony aches, low back pain, joint pain, restricted joint movement, a history of fractures from minor trauma, and delayed fracture healing. BLL, as well as serum levels of vitamin D3 and CTX-1, were measured in all participants.

Results: Smelter workers exhibited significantly higher prevalence of bony aches, low back pain, joint pain, and past fractures from minor trauma compared to controls. The BLL and serum CTX-1 levels were significantly elevated in the exposed group, while serum vitamin D3 levels were notably lower. Logistic regression analysis revealed that BLL significantly predicted bony aches and low back pain. Additionally, serum vitamin D3 and CTX-1 levels were significant predictors of low back pain and joint pain, respectively, among exposed workers. The measured parameters were significantly correlated with one another and with the duration of employment in the exposed group.

Conclusion: Significant associations between manifestations of skeletal system affection, BLL, and serum levels of vitamin D3 and CTX-1 were detected among smelter workers with chronic occupational exposure to Pb.

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来源期刊

International Archives of Occupational and Environmental Health 医学-公共卫生、环境卫生与职业卫生

CiteScore

5.60

自引率

6.70%

发文量

127

审稿时长

3 months

期刊介绍： International Archives of Occupational and Environmental Health publishes Editorials, Review Articles, Original Articles, and Letters to the Editor. It welcomes any manuscripts dealing with occupational or ambient environmental problems, with a special interest in research at the interface of occupational health and clinical medicine. The scope ranges from Biological Monitoring to Dermatology, from Fibers and Dust to Human Toxicology, from Nanomaterials and Ultra-fine Dust to Night- and Shift Work, from Psycho-mental Distress and Burnout to Vibrations. A complete list of topics can be found on the right-hand side under For authors and editors. In addition, all papers should be based on present-day standards and relate to: -Clinical and epidemiological studies on morbidity and mortality -Clinical epidemiological studies on the parameters relevant to the estimation of health risks -Human experimental studies on environmental health effects. Animal experiments are only acceptable if relevant to pathogenic aspects. -Methods for studying the topics mentioned above.