The association between occupational lead exposure and serum levels of vitamin D3 and a bone turnover biomarker in smelter workers.

IF 2.6 3区医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

International Archives of Occupational and Environmental Health Pub Date : 2025-04-01 Epub Date: 2025-03-08 DOI:10.1007/s00420-025-02125-y

Rateba Said Mohammed, Basma Hussein Mourad

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引用次数: 0

Abstract

Objective: Bone tissue is the chief target for lead (Pb) in chronic exposure. This study aimed to demonstrate the relation between the blood lead levels (BLL) and serum levels of 1,25 dihydroxy cholecalciferol (vitamin D3) and type I collagen cross-linked C-telopeptide (CTX-1) as a biomarker of bone turnover among some Egyptian workers occupationally exposed to Pb in the smelting process. The study also targeted to identify any clinical manifestations indicative of skeletal system affection and their association with the performed investigations.

Methods: A total of 48 smelter workers and 48 administrative controls participated in the study. All subjects underwent comprehensive medical and occupational history taking and detailed clinical examinations, with a particular focus on symptoms indicative of skeletal system involvement. These symptoms included generalized bony aches, low back pain, joint pain, restricted joint movement, a history of fractures from minor trauma, and delayed fracture healing. BLL, as well as serum levels of vitamin D3 and CTX-1, were measured in all participants.

Results: Smelter workers exhibited significantly higher prevalence of bony aches, low back pain, joint pain, and past fractures from minor trauma compared to controls. The BLL and serum CTX-1 levels were significantly elevated in the exposed group, while serum vitamin D3 levels were notably lower. Logistic regression analysis revealed that BLL significantly predicted bony aches and low back pain. Additionally, serum vitamin D3 and CTX-1 levels were significant predictors of low back pain and joint pain, respectively, among exposed workers. The measured parameters were significantly correlated with one another and with the duration of employment in the exposed group.

Conclusion: Significant associations between manifestations of skeletal system affection, BLL, and serum levels of vitamin D3 and CTX-1 were detected among smelter workers with chronic occupational exposure to Pb.

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冶炼厂工人职业性铅暴露与血清维生素D3水平和骨转换生物标志物之间的关系。

目的：骨组织是慢性铅暴露的主要靶组织。本研究旨在证明血铅水平（BLL）与血清中1,25二羟基胆骨化醇（维生素D3）和I型胶原交联c -末端肽（CTX-1）水平之间的关系，作为骨转换的生物标志物，在一些埃及职业铅冶炼过程中暴露于铅。该研究还旨在确定任何表明骨骼系统影响的临床表现及其与所进行的调查的关系。方法：共有48名冶炼工人和48名行政控制人员参与研究。所有受试者都进行了全面的医疗和职业史记录和详细的临床检查，特别关注骨骼系统受累的症状。这些症状包括全身骨痛、腰痛、关节痛、关节活动受限、有轻微外伤骨折史和骨折愈合延迟。对所有参与者的BLL以及血清维生素D3和CTX-1水平进行了测量。结果：与对照组相比，冶炼厂工人表现出明显更高的骨质疼痛、腰痛、关节痛和过去因轻微创伤而骨折的患病率。暴露组BLL和血清CTX-1水平显著升高，血清维生素D3水平显著降低。Logistic回归分析显示，BLL对骨痛和腰痛有显著预测作用。此外，血清维生素D3和CTX-1水平分别是暴露工人腰痛和关节痛的显著预测因子。所测参数之间存在显著相关性，且与暴露组的工作时间相关。结论：慢性职业性铅暴露的冶炼厂工人骨骼系统病变、BLL、血清维生素D3和CTX-1水平之间存在显著相关性。

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来源期刊

International Archives of Occupational and Environmental Health 医学-公共卫生、环境卫生与职业卫生

CiteScore

5.60

自引率

6.70%

发文量

127

审稿时长

3 months

期刊介绍： International Archives of Occupational and Environmental Health publishes Editorials, Review Articles, Original Articles, and Letters to the Editor. It welcomes any manuscripts dealing with occupational or ambient environmental problems, with a special interest in research at the interface of occupational health and clinical medicine. The scope ranges from Biological Monitoring to Dermatology, from Fibers and Dust to Human Toxicology, from Nanomaterials and Ultra-fine Dust to Night- and Shift Work, from Psycho-mental Distress and Burnout to Vibrations. A complete list of topics can be found on the right-hand side under For authors and editors. In addition, all papers should be based on present-day standards and relate to: -Clinical and epidemiological studies on morbidity and mortality -Clinical epidemiological studies on the parameters relevant to the estimation of health risks -Human experimental studies on environmental health effects. Animal experiments are only acceptable if relevant to pathogenic aspects. -Methods for studying the topics mentioned above.