Corticosteroid Administration Enhances the Glycemic, Insulinemic, and Incretin Responses to a High-Protein Mixed Meal in Adult Horses

IF 2.1 2区 农林科学 Q1 VETERINARY SCIENCES
Allison T. Palmer, Mauria R. Watts, Kathryn J. Timko, Erin F. Pinnell, Katelyn A. Keefer, Olivia Gorman, Laura D. Hostnik, Teresa A. Burns
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Abstract

Background

Corticosteroids are used routinely in horses and induce insulin dysregulation (ID). Nutrition is important for ID management and includes low nonstructural carbohydrate (NSC) diets and, often, high-protein ration balancers (RB). Insulin and incretin secretion increase after high-protein meals; corticosteroids may influence these effects.

Hypothesis

A high-protein mixed meal will induce hyperinsulinemia and increased concentrations of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) in horses with ID; dexamethasone (DEX) will amplify this effect.

Animals

Five horses with naturally occurring ID.

Methods

Horses underwent an IV glucose tolerance test and a feed challenge test (FCT; 1 kg RB). Tests were repeated after DEX administration (0.08 mg/kg PO q24h, 7 days). Insulin, glucose, and incretin dynamics were compared pre- and post-DEX.

Results

Corticosteroids exacerbated post-prandial hyperinsulinemia and hyperglycemia after a high-protein meal. The FCT area under the curve for insulin (AUCINS) after DEX was significantly higher than baseline (558 ± 182 μIU/mL × min vs. 257 ± 93.9 μIU/mL × min; p = 0.03). The maximum concentration of GIP (CmaxGIP) after DEX (381 ± 70.6 pg/mL) was significantly higher than baseline (262 ± 13.7 pg/mL; p = 0.013). The AUC for GLP-1 (AUCGLP-1; 31.1 ± 15.2 vs. 50 ± 20.2 pg/mL; p = 0.19) and the Cmax of GLP-1 (CmaxGLP-1; 39.1 ± 25.3 vs. 29.6 ± 12.2 pg/mL; p = 0.32) did not differ between DEX and baseline.

Conclusions and Clinical Importance

Metabolic responses to a high-protein mixed meal were exacerbated by corticosteroids. Horses receiving corticosteroids had larger GIP responses, which may enhance post-prandial hyperinsulinemia.

Abstract Image

皮质类固醇的使用增强了成年马对高蛋白混合饲料的血糖、胰岛素和肠促胰岛素反应
研究背景:皮质类固醇在马的常规使用中会引起胰岛素失调(ID)。营养对ID管理很重要,包括低非结构性碳水化合物(NSC)饮食和高蛋白日粮平衡(RB)。高蛋白餐后胰岛素和肠促胰岛素分泌增加;皮质类固醇可能影响这些作用。假设高蛋白混合膳食会导致ID马高胰岛素血症和葡萄糖依赖性胰岛素性多肽(GIP)和胰高血糖素样肽1 (GLP-1)浓度升高;地塞米松(DEX)会放大这种效果。五匹马,自然产生的ID。方法对马进行静脉葡萄糖耐量试验和饲料激发试验(FCT;1 kg RB)。给药后(0.08 mg/kg PO q24h, 7 d)重复试验。胰岛素,葡萄糖和肠促胰岛素动态比较前后dex。结果糖皮质激素加重高蛋白餐后高胰岛素血症和高血糖。DEX治疗后胰岛素(AUCINS)曲线下FCT面积显著高于基线(558±182 μIU/mL × min vs 257±93.9 μIU/mL × min);p = 0.03)。DEX后最大GIP浓度(CmaxGIP)(381±70.6 pg/mL)显著高于基线(262±13.7 pg/mL);p = 0.013)。GLP-1的AUC (AUCGLP-1;31.1±15.2 vs. 50±20.2 pg/mL;p = 0.19)和GLP-1的Cmax (CmaxGLP-1;39.1±25.3 vs. 29.6±12.2 pg/mL;p = 0.32), DEX与基线无差异。结论及临床意义糖皮质激素可加重高蛋白混合餐的代谢反应。接受皮质类固醇的马有更大的GIP反应,这可能会增强餐后高胰岛素血症。
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来源期刊
CiteScore
4.50
自引率
11.50%
发文量
243
审稿时长
22 weeks
期刊介绍: The mission of the Journal of Veterinary Internal Medicine is to advance veterinary medical knowledge and improve the lives of animals by publication of authoritative scientific articles of animal diseases.
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