Performance evaluation of green and conventional solvents in reversed-phase liquid chromatography based on the separation of non-polar and polar substances

IF 9.3 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Green Chemistry Pub Date : 2025-02-12 DOI:10.1039/D4GC05737F

Oktawia Kalisz, Gabriela Hulicka, Marek Tobiszewski and Szymon Bocian

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Abstract

This study investigated the potential for replacing conventional solvents such as acetonitrile (ACN) and methanol (MeOH) with greener alternatives – ethanol (EtOH) and dimethyl carbonate (DMC) – in chromatographic separations. The aim was to assess whether these environmentally friendly solvents could achieve comparable separation performance while reducing the environmental impact of the analyses. Chromatographic separations were carried out on two different mixtures: non-polar and polar, using three stationary phases with different surface properties (C18, diphenyl and perfluorinated phenyl). The Technique for Order of Preference by Similarity to Ideal Solution algorithm (TOPSIS) was used to select the optimal conditions for ultra-high performance liquid chromatography (UHPLC) separations, integrating multiple criteria, including chromatographic run time, tailing ratios, resolution and solvent-related environmental hazards. The results show that EtOH and DMC can effectively replace traditional solvents without compromising separation performance, confirming that sustainable analytical methods for mixtures of non-polar and polar compounds are achievable with green solvents.

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来源期刊

Green Chemistry 化学-化学综合

CiteScore

16.10

自引率

7.10%

发文量

677

审稿时长

1.4 months

期刊介绍： Green Chemistry is a journal that provides a unique forum for the publication of innovative research on the development of alternative green and sustainable technologies. The scope of Green Chemistry is based on the definition proposed by Anastas and Warner (Green Chemistry: Theory and Practice, P T Anastas and J C Warner, Oxford University Press, Oxford, 1998), which defines green chemistry as the utilisation of a set of principles that reduces or eliminates the use or generation of hazardous substances in the design, manufacture and application of chemical products. Green Chemistry aims to reduce the environmental impact of the chemical enterprise by developing a technology base that is inherently non-toxic to living things and the environment. The journal welcomes submissions on all aspects of research relating to this endeavor and publishes original and significant cutting-edge research that is likely to be of wide general appeal. For a work to be published, it must present a significant advance in green chemistry, including a comparison with existing methods and a demonstration of advantages over those methods.