Hydrogen generators in medical cyclotrons: A preliminary evaluation

IF 2.8 3区物理与天体物理 Q3 CHEMISTRY, PHYSICAL

Radiation Physics and Chemistry Pub Date : 2025-03-04 DOI:10.1016/j.radphyschem.2025.112668

Elena Miñana Olmo, Tomás Chivato Martín-Falquina

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Abstract

Positron Emission Tomography (PET) has witnessed significant advances in radiopharmaceuticals and imaging technology, broadening its applications across oncology, neurology, and cardiology. PET radiopharmaceuticals are predominantly produced in cyclotrons. Hydrogen, a key element in cyclotron operation, is traditionally supplied via gas cylinders, posing challenges in purity, safety, and handling. This study evaluates the feasibility of using a hydrogen generator to supply high-purity hydrogen (grade 7.0) to a cyclotron's ion source (IS) for fluorine-18 production. A hydrogen generator was integrated with a PETtrace 880 cyclotron, and its performance was compared to conventional hydrogen cylinders across 34 irradiation runs of varying batch sizes. Results indicate that the test achieved consistent activity yields, stable hydrogen flow, and required lower arc current in the IS per unit of beam current, indicating higher efficiency. Additionally, the hydrogen generator offers safety benefits by minimizing high-pressure gas storage. While the device requires higher initial investment, its operational simplicity and potential to extend IS lifespan make it a viable alternative. Further studies are recommended to assess long-term impact and performance.

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来源期刊

Radiation Physics and Chemistry 化学-核科学技术

CiteScore

5.60

自引率

17.20%

发文量

574

审稿时长

12 weeks

期刊介绍： Radiation Physics and Chemistry is a multidisciplinary journal that provides a medium for publication of substantial and original papers, reviews, and short communications which focus on research and developments involving ionizing radiation in radiation physics, radiation chemistry and radiation processing. The journal aims to publish papers with significance to an international audience, containing substantial novelty and scientific impact. The Editors reserve the rights to reject, with or without external review, papers that do not meet these criteria. This could include papers that are very similar to previous publications, only with changed target substrates, employed materials, analyzed sites and experimental methods, report results without presenting new insights and/or hypothesis testing, or do not focus on the radiation effects.