Subcutaneous undifferentiated pleomorphic sarcoma is more aggressive than pleomorphic dermal sarcoma: Prognosis from a Danish nationwide registry-based cohort

IF 3.5 2区医学 Q2 ONCOLOGY

Ejso Pub Date : 2025-03-05 DOI:10.1016/j.ejso.2025.109747

Mathias Ørholt , Ida Wulff , Kiya Abebe , Tim K. Weltz , Mathilde N. Hemmingsen , Anne L. Wagenblast , Grethe Schmidt , David H. Jensen , Michael M. Petersen , Anand C. Loya , Søren Daugaard , Thomas Mentzel , Mikkel Herly , Peter Vester-Glowinski

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Abstract

Introduction

Subcutaneous undifferentiated pleomorphic sarcoma (scUPS) has not previously been described separately from pleomorphic dermal sarcoma (PDS), and consequently the prognosis for patients with scUPS is unknown.

Materials and methods

In this nationwide cohort study, we identified all patients in Denmark diagnosed with scUPS or PDS between 2002 and 2022. The outcomes were 5-year local recurrence, loco-regional and distant metastasis, and overall survival.

Results

We included 271 patients, 131 with scUPS and 140 with PDS. Patients with scUPS exhibited higher 5-year risks than patients with PDS in terms of the overall risk of metastasis (19 % vs. 7 %, p = 0.006) and distant metastasis only (12 % vs. 2 %, p = 0.004). The 5-year overall survival for patients with scUPS was 50 %, compared to 67 % for patients with PDS (p = 0.004).

Conclusion

Our findings indicate that patients with scUPS have a significantly worse prognosis than patients with PDS, with a higher overall risk of metastasis and a prolonged metastatic risk. This suggests a more extended follow-up program focusing on the detection of distant metastasis for patients with scUPS, whereas the follow-up of patients with PDS can be limited to clinical controls.

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来源期刊

Ejso 医学-外科

CiteScore

6.40

自引率

2.60%

发文量

1148

审稿时长

41 days

期刊介绍： JSO - European Journal of Surgical Oncology ("the Journal of Cancer Surgery") is the Official Journal of the European Society of Surgical Oncology and BASO ~ the Association for Cancer Surgery. The EJSO aims to advance surgical oncology research and practice through the publication of original research articles, review articles, editorials, debates and correspondence.