Comparison of patients presenting to emergency departments infected with respiratory syncytial virus versus influenza virus: A retrospective cohort study

IF 4 3区医学 Q2 VIROLOGY

Journal of Clinical Virology Pub Date : 2025-03-07 DOI:10.1016/j.jcv.2025.105775

Karine Alamé , Quentin Le Hingrat , Pierre Catoire , Richard Chocron , Xavier Eyer , Christelle Hermand , Judith Gorlicki , Sarah Addou , Ségolène Brichler , Maud Salmona , David Veyer , Stéphane Marot , Aurélie Schnuriger , Yonathan Freund , Donia Bouzid

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引用次数: 0

Abstract

Objective

In recent years, there has been increased awareness of the impact of respiratory syncytial virus (RSV) on adult health, especially in elderly patients. Unlike influenza infection, its presentation and patient outcomes are not well studied. The aim of this study was to compare clinical outcomes in emergency department patients infected by RSV vs influenza.

Methods

This was a multicenter retrospective study in seven emergency departments (ED) in France. Patients with a laboratory-confirmed RSV or influenza infection in the ED were included between January 2017 and December 2022. The primary endpoint was in-hospital mortality truncated at day 28. Secondary endpoints included one year occurrence of thrombo-embolic event, acute coronary syndrome, and stroke.

Results

3397 patient charts were screened, and 3224 were analyzed. Of these, 551 (17 %) patients had RSV-positive PCR, and 2673 (83 %) had influenza-positive PCR. Patients with RSV were older (median age 73 vs. 68; difference, −5.00 % points [CI, −4.0 to −6.0 % points])), and had more comorbidities (15.0 % vs 22.0 % difference, −6.92 % points [CI, −10.6 to −3.21 % points])), compared to those with influenza. There was no significant difference in in-hospital mortality rate at day 28: 3.82 % for influenza vs. 4.72 % for RSV (adjusted OR 0.93, 95 %CI [0.59–1.46] p = 0.73). There was no significant difference in the occurrence of the secondary endpoints.

Conclusions

In this large study of ED patients, although RSV patients were more fragile, no significant differences were found in in-hospital mortality or the occurrence of cardiovascular or thromboembolic events between RSV and influenza infections.

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来源期刊

Journal of Clinical Virology 医学-病毒学

CiteScore

22.70

自引率

1.10%

发文量

149

审稿时长

24 days

期刊介绍： The Journal of Clinical Virology, an esteemed international publication, serves as the official journal for both the Pan American Society for Clinical Virology and The European Society for Clinical Virology. Dedicated to advancing the understanding of human virology in clinical settings, the Journal of Clinical Virology focuses on disseminating research papers and reviews pertaining to the clinical aspects of virology. Its scope encompasses articles discussing diagnostic methodologies and virus-induced clinical conditions, with an emphasis on practicality and relevance to clinical practice. The journal publishes on topics that include: • new diagnostic technologies • nucleic acid amplification and serologic testing • targeted and metagenomic next-generation sequencing • emerging pandemic viral threats • respiratory viruses • transplant viruses • chronic viral infections • cancer-associated viruses • gastrointestinal viruses • central nervous system viruses • one health (excludes animal health)