Comparison of patients presenting to emergency departments infected with respiratory syncytial virus versus influenza virus: A retrospective cohort study

IF 4 3区医学 Q2 VIROLOGY

Journal of Clinical Virology Pub Date : 2025-03-07 DOI:10.1016/j.jcv.2025.105775

Karine Alamé , Quentin Le Hingrat , Pierre Catoire , Richard Chocron , Xavier Eyer , Christelle Hermand , Judith Gorlicki , Sarah Addou , Ségolène Brichler , Maud Salmona , David Veyer , Stéphane Marot , Aurélie Schnuriger , Yonathan Freund , Donia Bouzid

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引用次数: 0

Abstract

Objective

In recent years, there has been increased awareness of the impact of respiratory syncytial virus (RSV) on adult health, especially in elderly patients. Unlike influenza infection, its presentation and patient outcomes are not well studied. The aim of this study was to compare clinical outcomes in emergency department patients infected by RSV vs influenza.

Methods

This was a multicenter retrospective study in seven emergency departments (ED) in France. Patients with a laboratory-confirmed RSV or influenza infection in the ED were included between January 2017 and December 2022. The primary endpoint was in-hospital mortality truncated at day 28. Secondary endpoints included one year occurrence of thrombo-embolic event, acute coronary syndrome, and stroke.

Results

3397 patient charts were screened, and 3224 were analyzed. Of these, 551 (17 %) patients had RSV-positive PCR, and 2673 (83 %) had influenza-positive PCR. Patients with RSV were older (median age 73 vs. 68; difference, −5.00 % points [CI, −4.0 to −6.0 % points])), and had more comorbidities (15.0 % vs 22.0 % difference, −6.92 % points [CI, −10.6 to −3.21 % points])), compared to those with influenza. There was no significant difference in in-hospital mortality rate at day 28: 3.82 % for influenza vs. 4.72 % for RSV (adjusted OR 0.93, 95 %CI [0.59–1.46] p = 0.73). There was no significant difference in the occurrence of the secondary endpoints.

Conclusions

In this large study of ED patients, although RSV patients were more fragile, no significant differences were found in in-hospital mortality or the occurrence of cardiovascular or thromboembolic events between RSV and influenza infections.

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急诊患者呼吸道合胞病毒感染与流感病毒感染的比较：一项回顾性队列研究

目的近年来，呼吸道合胞病毒（RSV）对成人特别是老年患者健康影响的认识日益提高。与流感感染不同，其表现和患者预后尚未得到很好的研究。本研究的目的是比较急诊科感染RSV和流感患者的临床结果。方法对法国7个急诊科（ED）进行多中心回顾性研究。纳入了2017年1月至2022年12月期间在急诊科实验室确诊的RSV或流感感染患者。主要终点是第28天的住院死亡率。次要终点包括一年内发生血栓栓塞事件、急性冠状动脉综合征和中风。结果共筛选患者病历3397份，分析病历3224份。其中，551例（17%）患者PCR呈rsv阳性，2673例（83%）PCR呈流感阳性。RSV患者年龄较大(中位年龄73 vs 68；差异，−5.00个百分点[CI，−4.0至−6.0个百分点])))，并且与流感患者相比有更多的合并症（15.0% vs 22.0%差异，−6.92个百分点[CI，−10.6至−3.21个百分点]）)。第28天的住院死亡率无显著差异：流感患者为3.82%，RSV患者为4.72%（校正OR 0.93, 95% CI [0.59-1.46] p = 0.73）。次要终点的发生率无显著差异。结论在这项针对ED患者的大型研究中，虽然RSV患者更脆弱，但在院内死亡率、心血管或血栓栓塞事件的发生方面，RSV与流感感染之间没有显著差异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Clinical Virology 医学-病毒学

CiteScore

22.70

自引率

1.10%

发文量

149

审稿时长

24 days

期刊介绍： The Journal of Clinical Virology, an esteemed international publication, serves as the official journal for both the Pan American Society for Clinical Virology and The European Society for Clinical Virology. Dedicated to advancing the understanding of human virology in clinical settings, the Journal of Clinical Virology focuses on disseminating research papers and reviews pertaining to the clinical aspects of virology. Its scope encompasses articles discussing diagnostic methodologies and virus-induced clinical conditions, with an emphasis on practicality and relevance to clinical practice. The journal publishes on topics that include: • new diagnostic technologies • nucleic acid amplification and serologic testing • targeted and metagenomic next-generation sequencing • emerging pandemic viral threats • respiratory viruses • transplant viruses • chronic viral infections • cancer-associated viruses • gastrointestinal viruses • central nervous system viruses • one health (excludes animal health)