Prenatal exposure to organochlorine pesticides and polychlorinated biphenyls and risk of testicular germ cell cancer later in life

IF 8.2 1区环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES

Science of the Total Environment Pub Date : 2025-03-09 DOI:10.1016/j.scitotenv.2025.179054

Cecilie S. Uldbjerg , Panu Rantakokko , Youn-Hee Lim , Jørgen H. Petersen , Karina M. Sørensen , Brent A. Coull , Christian Lindh , Russ Hauser , Elvira V. Bräuner , Niels E. Skakkebæk , Lærke Priskorn , Anders Juul

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引用次数: 0

Abstract

Introduction

Exposure to environmental chemicals during fetal development may increase the risk of testicular germ cell cancer (TGCC), but few studies have tested the hypothesis. We focused on organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs), previously investigated in relation to other male reproductive health outcomes.

Methods

We conducted a nested case-control study of 332 mother-son pairs, comprising 65 TGCC cases and 267 controls, identified from a Danish Pregnancy Screening Registry with biobanked serum samples collected from pregnant women in 1985–1995, when exposure to the studied chemicals was relatively high. We quantified seven OCPs and 13 PCB congeners in maternal serum by gas chromatography tandem mass spectrometry. TGCC diagnoses and covariate information were derived from the nationwide Danish registries. We estimated associations between individual chemicals and their mixture with the risk of TGCC through adapted Cox regression and quantile g-computation models.

Results

Median age at TGCC diagnosis was 24.7 years. In main analyses, associations between individual OCPs and PCBs and risk of TGCC showed either slightly higher risks or no association (close to Hazard Ratios (HR) of 1.00), with confidence intervals overlapping unity. In mixture analyses, simultaneously increasing all chemical concentrations by one quartile resulted in a slightly higher risk of TGCC (HR 1.11, 95 % CI: 0.61; 2.05) after adjusting for confounders. Sensitivity analyses investigating tertiles of concentrations did not change the overall pattern of results.

Conclusions

Prenatal exposure to OCPs and PCBs, quantified by concentrations in maternal pregnancy serum, was not associated with later risk of TGCC.

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产前暴露于有机氯农药和多氯联苯与晚年睾丸生殖细胞癌的风险

胎儿发育期间暴露于环境化学物质可能会增加睾丸生殖细胞癌（TGCC）的风险，但很少有研究证实了这一假设。我们的重点是有机氯农药（ocp）和多氯联苯（PCBs），之前研究了它们与其他男性生殖健康结果的关系。方法：我们对332对母子进行了巢式病例对照研究，其中包括65例TGCC病例和267例对照，这些病例来自丹麦妊娠筛查登记处，收集了1985-1995年间孕妇的生物库血清样本，当时所研究的化学物质暴露相对较高。采用气相色谱-串联质谱法对母体血清中7种OCPs和13种PCB同源物进行了定量分析。TGCC诊断和协变量信息来自丹麦全国登记。我们通过适应性Cox回归和分位数g计算模型估计了个体化学物质及其混合物与TGCC风险之间的关联。结果TGCC诊断的中位年龄为24.7岁。在主要分析中，个体ocp和PCBs与TGCC风险之间的关联显示出略高的风险或无关联（接近1.00的风险比（HR）），置信区间重叠统一。在混合分析中，同时增加四分之一的所有化学物质浓度导致TGCC的风险略高(HR 1.11, 95% CI: 0.61；2.05)调整混杂因素后。敏感性分析调查浓度的位数并没有改变结果的总体模式。结论产前暴露于多氯联苯和多氯联苯与晚期TGCC风险无关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Science of the Total Environment 环境科学-环境科学

CiteScore

17.60

自引率

10.20%

发文量

8726

审稿时长

2.4 months

期刊介绍： The Science of the Total Environment is an international journal dedicated to scientific research on the environment and its interaction with humanity. It covers a wide range of disciplines and seeks to publish innovative, hypothesis-driven, and impactful research that explores the entire environment, including the atmosphere, lithosphere, hydrosphere, biosphere, and anthroposphere. The journal's updated Aims & Scope emphasizes the importance of interdisciplinary environmental research with broad impact. Priority is given to studies that advance fundamental understanding and explore the interconnectedness of multiple environmental spheres. Field studies are preferred, while laboratory experiments must demonstrate significant methodological advancements or mechanistic insights with direct relevance to the environment.