Prenatal exposure to organochlorine pesticides and polychlorinated biphenyls and risk of testicular germ cell cancer later in life

IF 8.2 1区环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES

Science of the Total Environment Pub Date : 2025-03-09 DOI:10.1016/j.scitotenv.2025.179054

Cecilie S. Uldbjerg , Panu Rantakokko , Youn-Hee Lim , Jørgen H. Petersen , Karina M. Sørensen , Brent A. Coull , Christian Lindh , Russ Hauser , Elvira V. Bräuner , Niels E. Skakkebæk , Lærke Priskorn , Anders Juul

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引用次数: 0

Abstract

Introduction

Exposure to environmental chemicals during fetal development may increase the risk of testicular germ cell cancer (TGCC), but few studies have tested the hypothesis. We focused on organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs), previously investigated in relation to other male reproductive health outcomes.

Methods

We conducted a nested case-control study of 332 mother-son pairs, comprising 65 TGCC cases and 267 controls, identified from a Danish Pregnancy Screening Registry with biobanked serum samples collected from pregnant women in 1985–1995, when exposure to the studied chemicals was relatively high. We quantified seven OCPs and 13 PCB congeners in maternal serum by gas chromatography tandem mass spectrometry. TGCC diagnoses and covariate information were derived from the nationwide Danish registries. We estimated associations between individual chemicals and their mixture with the risk of TGCC through adapted Cox regression and quantile g-computation models.

Results

Median age at TGCC diagnosis was 24.7 years. In main analyses, associations between individual OCPs and PCBs and risk of TGCC showed either slightly higher risks or no association (close to Hazard Ratios (HR) of 1.00), with confidence intervals overlapping unity. In mixture analyses, simultaneously increasing all chemical concentrations by one quartile resulted in a slightly higher risk of TGCC (HR 1.11, 95 % CI: 0.61; 2.05) after adjusting for confounders. Sensitivity analyses investigating tertiles of concentrations did not change the overall pattern of results.

Conclusions

Prenatal exposure to OCPs and PCBs, quantified by concentrations in maternal pregnancy serum, was not associated with later risk of TGCC.

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来源期刊

Science of the Total Environment 环境科学-环境科学

CiteScore

17.60

自引率

10.20%

发文量

8726

审稿时长

2.4 months

期刊介绍： The Science of the Total Environment is an international journal dedicated to scientific research on the environment and its interaction with humanity. It covers a wide range of disciplines and seeks to publish innovative, hypothesis-driven, and impactful research that explores the entire environment, including the atmosphere, lithosphere, hydrosphere, biosphere, and anthroposphere. The journal's updated Aims & Scope emphasizes the importance of interdisciplinary environmental research with broad impact. Priority is given to studies that advance fundamental understanding and explore the interconnectedness of multiple environmental spheres. Field studies are preferred, while laboratory experiments must demonstrate significant methodological advancements or mechanistic insights with direct relevance to the environment.