Association between ABO (H) secretory status and rheumatoid arthritis

IF 1 Q4 GENETICS & HEREDITY

Gene Reports Pub Date : 2025-03-07 DOI:10.1016/j.genrep.2025.102193

Sajedeh Saharkhiz , Fatemeh Pouladkhay , Fatemeh Ghorbani , Farzaneh Afzali , Farhang Soltani Bajestan , Jafar Hajavi , Mohammad Amin Momeni-Moghaddam , Majid Zamani

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Abstract

Introduction

ABH antigens are present on the surface of blood cells and in body secretions such as saliva. Our study aimed to investigate the frequency distribution of secretor and non-secretor phenotypes among patients with rheumatoid arthritis. The lack of blood group antigens in body secretions increases the incidence of certain diseases, including autoimmune diseases and infections.

Methods

This case-control study was conducted on 250 patients referred to Allameh Bohloul Gonabadi Hospital. 120 patients had rheumatoid arthritis and 130 controls without rheumatoid arthritis. 2 mL of saliva was collected from the patients non-invasively. We determined the secretory and non-secretory status of the patients by examining agglutination or non-agglutination by visual and microscopic methods.

Results

Secretory status in the case group, 75 out of 120 patients (62.5 %) were secretory and 45 (37.5 %) were non-secretory. In the control group, 120 out of 130 patients (92.3 %) were secretory and 10 (7.7 %) were non-secretory. Non-secretors were significantly more associated with rheumatoid arthritis (P < 0.05).

Conclusions

The non-secretory of ABH substances may be associated with rheumatoid arthritis and these results were found more in women than in men, Although, to investigate whether the increased frequency of with rheumatoid arthritis among non-secretors is coincidental or indeed genetic, a prospective cohort study of non-secretors in relation to with rheumatoid arthritis is required.

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来源期刊

Gene Reports Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

3.30

自引率

7.70%

发文量

246

审稿时长

49 days

期刊介绍： Gene Reports publishes papers that focus on the regulation, expression, function and evolution of genes in all biological contexts, including all prokaryotic and eukaryotic organisms, as well as viruses. Gene Reports strives to be a very diverse journal and topics in all fields will be considered for publication. Although not limited to the following, some general topics include: DNA Organization, Replication & Evolution -Focus on genomic DNA (chromosomal organization, comparative genomics, DNA replication, DNA repair, mobile DNA, mitochondrial DNA, chloroplast DNA). Expression & Function - Focus on functional RNAs (microRNAs, tRNAs, rRNAs, mRNA splicing, alternative polyadenylation) Regulation - Focus on processes that mediate gene-read out (epigenetics, chromatin, histone code, transcription, translation, protein degradation). Cell Signaling - Focus on mechanisms that control information flow into the nucleus to control gene expression (kinase and phosphatase pathways controlled by extra-cellular ligands, Wnt, Notch, TGFbeta/BMPs, FGFs, IGFs etc.) Profiling of gene expression and genetic variation - Focus on high throughput approaches (e.g., DeepSeq, ChIP-Seq, Affymetrix microarrays, proteomics) that define gene regulatory circuitry, molecular pathways and protein/protein networks. Genetics - Focus on development in model organisms (e.g., mouse, frog, fruit fly, worm), human genetic variation, population genetics, as well as agricultural and veterinary genetics. Molecular Pathology & Regenerative Medicine - Focus on the deregulation of molecular processes in human diseases and mechanisms supporting regeneration of tissues through pluripotent or multipotent stem cells.