Advanced therapeutic strategies using Thermo-sensitive chitosan/pectin hydrogel in the treatment of multiple cancers

Abstract

Current cancer therapies including immunotherapy and chemotherapy produce adverse side effects that demand improved drug distribution methods. Research shows that thermosensitive chitosan/pectin-based hydrogels serve as an effective platform technology for drug delivery during cancer therapy because of their ability to control drug release at specific locations. The hydrogels perform temperature-triggered sol-gel phase shifts which enables prolonged drug delivery together with minimal toxic side effects. The biocompatible and biodegradable properties of these materials enable solutions against drug resistance and tumour heterogeneity challenges. Studies have demonstrated that these hydrogels enhance drug bioavailability, extend circulation time, and improve tumour targeting, leading to increased therapeutic efficacy and reduced systemic toxicity. Their ability to sustain drug release and penetrate tumour microenvironments makes them a promising strategy for overcoming drug resistance and tumour heterogeneity. Their ability to reproduce native tissue properties poses challenges that scientists must address through improved structural optimization approaches. The combination of latest nanotechnology innovations and interdisciplinary studies has sped up the creation of chitosan/pectin hydrogels for cancer treatment applications. This review highlights the significant advancements and demonstrated effectiveness of thermosensitive chitosan/pectin hydrogels in cancer treatment by exploring their design parameters alongside their drug release behaviour while discussing their potential medical applications.