Diterpenoids and tannins from Cleidion brevipetiolatum

IF 2.5 3区医学 Q3 CHEMISTRY, MEDICINAL

Fitoterapia Pub Date : 2025-03-07 DOI:10.1016/j.fitote.2025.106464

Bang-Yong Wang , Wei Wei , Jin-Ni Tan , Rui-Jing Ma , Chun-Hua Lai , Qin-Gang Tan

引用次数: 0

Abstract

Four undescribed clerodane diterpenoids cleibreciums A-D (1–4) and two undescribed ellagitannins, 2′-methoxybractin (5) and 3″‘-hydroxy-5″‘-dehydroxy-2′-methoxybractin (6) were isolated from the aqueous-EtOH extract of twigs and leaves of Cleidion brevipetiolatum. Their structures were elucidated by extensive spectroscopic analysis, including NMR and HRESIMS, as well as X-ray crystallographic analysis. Anti-inflammatory assay showed that compounds 2 and 6 exhibited weak inhibitory activity on the nitric oxide (NO) production in the lipopolysaccharide (LPS)-induced RAW 264.7 cells.

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来源期刊

Fitoterapia 医学-药学

CiteScore

5.80

自引率

2.90%

发文量

198

审稿时长

1.5 months

期刊介绍： Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas: 1. Characterization of active ingredients of medicinal plants 2. Development of standardization method for bioactive plant extracts and natural products 3. Identification of bioactivity in plant extracts 4. Identification of targets and mechanism of activity of plant extracts 5. Production and genomic characterization of medicinal plants biomass 6. Chemistry and biochemistry of bioactive natural products of plant origin 7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.