Biomembranes Based on Potato Starch Modified by Dry Heating Treatment: One Sustainable Strategy to Amplify the Use of Starch as a Biomaterial

IF 5.4 2区化学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biomacromolecules Pub Date : 2025-02-24 DOI:10.1021/acs.biomac.4c0129410.1021/acs.biomac.4c01294

Pedro Augusto Invernizzi Sponchiado, Maryanne Trafani Melo, Juçara G. Cominal, Milena Martelli Tosi, Pietro Ciancaglini, Ana Paula Ramos and Bianca Chieregato Maniglia*,

{"title":"Biomembranes Based on Potato Starch Modified by Dry Heating Treatment: One Sustainable Strategy to Amplify the Use of Starch as a Biomaterial","authors":"Pedro Augusto Invernizzi Sponchiado, Maryanne Trafani Melo, Juçara G. Cominal, Milena Martelli Tosi, Pietro Ciancaglini, Ana Paula Ramos and Bianca Chieregato Maniglia*, ","doi":"10.1021/acs.biomac.4c0129410.1021/acs.biomac.4c01294","DOIUrl":null,"url":null,"abstract":"<p >The exceptional biocompatibility of polymeric membranes drives their use in biomaterials, but structural modifications are needed to improve their mechanical properties. This study investigated dry heating treatment (DHT) as an ecofriendly and cost-effective approach to modifying potato starch for biomembrane fabrication. DHT-treated starch (2 h) produced biomembranes with a denser structure, smoother surfaces, and significantly improved mechanical properties, including higher tensile strength (∼6×), rigidity (∼15×), and relative crystallinity (∼2×) while reducing flexibility (∼5×), compared to native starch membranes. These membranes also exhibited lower moisture content, reduced hydrophilicity, higher surface energy, decreased biodegradability, and enhanced bioactivity, as shown by hydroxyapatite formation in simulated body fluid. Importantly, they were nontoxic to osteoblasts, emphasizing their potential for medical applications. This study highlights DHT as a sustainable and innovative method for modifying starch to develop advanced biomaterials for medical applications.</p>","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":"26 3","pages":"1530–1540 1530–1540"},"PeriodicalIF":5.4000,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acs.biomac.4c01294","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biomacromolecules","FirstCategoryId":"92","ListUrlMain":"https://pubs.acs.org/doi/10.1021/acs.biomac.4c01294","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

The exceptional biocompatibility of polymeric membranes drives their use in biomaterials, but structural modifications are needed to improve their mechanical properties. This study investigated dry heating treatment (DHT) as an ecofriendly and cost-effective approach to modifying potato starch for biomembrane fabrication. DHT-treated starch (2 h) produced biomembranes with a denser structure, smoother surfaces, and significantly improved mechanical properties, including higher tensile strength (∼6×), rigidity (∼15×), and relative crystallinity (∼2×) while reducing flexibility (∼5×), compared to native starch membranes. These membranes also exhibited lower moisture content, reduced hydrophilicity, higher surface energy, decreased biodegradability, and enhanced bioactivity, as shown by hydroxyapatite formation in simulated body fluid. Importantly, they were nontoxic to osteoblasts, emphasizing their potential for medical applications. This study highlights DHT as a sustainable and innovative method for modifying starch to develop advanced biomaterials for medical applications.

查看原文本刊更多论文

马铃薯淀粉干热改性生物膜：一种扩大淀粉作为生物材料使用的可持续策略

聚合物膜优异的生物相容性促使其在生物材料中的应用，但需要对其结构进行修饰以提高其机械性能。本研究研究了干热处理（DHT）作为一种环保和经济有效的方法来改性马铃薯淀粉，用于制备生物膜。与天然淀粉膜相比，dht处理的淀粉（2小时）产生的生物膜具有更致密的结构，更光滑的表面，并显着改善了机械性能，包括更高的抗拉强度（~ 6x），刚性（~ 15x）和相对结晶度（~ 2x），同时降低了灵活性（~ 5x）。模拟体液中羟基磷灰石的形成表明，这些膜的含水量更低，亲水性降低，表面能更高，生物降解性降低，生物活性增强。重要的是，它们对成骨细胞无毒，强调了它们在医学上的应用潜力。本研究强调了DHT作为一种可持续和创新的方法来修饰淀粉，以开发先进的医用生物材料。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Biomacromolecules 化学-高分子科学

CiteScore

10.60

自引率

4.80%

发文量

417

审稿时长

1.6 months

期刊介绍： Biomacromolecules is a leading forum for the dissemination of cutting-edge research at the interface of polymer science and biology. Submissions to Biomacromolecules should contain strong elements of innovation in terms of macromolecular design, synthesis and characterization, or in the application of polymer materials to biology and medicine. Topics covered by Biomacromolecules include, but are not exclusively limited to: sustainable polymers, polymers based on natural and renewable resources, degradable polymers, polymer conjugates, polymeric drugs, polymers in biocatalysis, biomacromolecular assembly, biomimetic polymers, polymer-biomineral hybrids, biomimetic-polymer processing, polymer recycling, bioactive polymer surfaces, original polymer design for biomedical applications such as immunotherapy, drug delivery, gene delivery, antimicrobial applications, diagnostic imaging and biosensing, polymers in tissue engineering and regenerative medicine, polymeric scaffolds and hydrogels for cell culture and delivery.