Optical Metasurfaces for the Next-Generation Biosensing and Bioimaging

IF 9.8 1区 物理与天体物理 Q1 OPTICS
Anthony J. El-Helou, Yiting Liu, Chaohao Chen, Fan Wang, Hatice Altug, Peter J. Reece, Ying Zhu
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引用次数: 0

Abstract

Recent advances in this understanding of light-matter interactions, combined with innovations in the design and fabrication of large-scale nanostructured metasurfaces, have enabled transformative approaches to biosensing and bioimaging. This review delves into the profound impact of optical metasurfaces, highlighting innovations that leverage their tunable properties and adaptability. It begins with an overview of key sensing mechanisms across various metasurface modalities, comparing their effects on metrics such as sensitivity and limits of detection. The discussion then shifts to recent advancements in refractometric biosensing, focusing on novel transduction methods that exploit the intensity, phase, and colorimetric responses of these metasurfaces. The latest developments in surface-enhanced spectroscopic sensing are also examined, exploring how metasurfaces contribute to enhanced molecular fingerprinting capabilities in these applications. Additionally, the role of optical metasurfaces in advancing bioimaging are assessed, emphasizing label-free elastic scattering, spectroscopic/chemical contrast imaging, and metasurface-assisted super-resolution microscopy. Finally, the review addresses current challenges and future directions for optical metasurfaces in biosensing and imaging, including material limitations, difficulties in large-scale fabrication, and the complexity of data analysis and readout methods. It also discusses the integration of novel detector hardware to improve spatiotemporal resolution of sensing and imaging techniques.

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来源期刊
CiteScore
14.20
自引率
5.50%
发文量
314
审稿时长
2 months
期刊介绍: Laser & Photonics Reviews is a reputable journal that publishes high-quality Reviews, original Research Articles, and Perspectives in the field of photonics and optics. It covers both theoretical and experimental aspects, including recent groundbreaking research, specific advancements, and innovative applications. As evidence of its impact and recognition, Laser & Photonics Reviews boasts a remarkable 2022 Impact Factor of 11.0, according to the Journal Citation Reports from Clarivate Analytics (2023). Moreover, it holds impressive rankings in the InCites Journal Citation Reports: in 2021, it was ranked 6th out of 101 in the field of Optics, 15th out of 161 in Applied Physics, and 12th out of 69 in Condensed Matter Physics. The journal uses the ISSN numbers 1863-8880 for print and 1863-8899 for online publications.
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