Infection in patients with burn injury: sources, pathogens, sensitivity, and role of empirical antibiotics therapy.

IF 1.4 4区医学 Q3 DERMATOLOGY

Wounds : a compendium of clinical research and practice Pub Date : 2025-02-01

Olayinka Adebanji Olawoye, Chinsunum Peace Isamah, Samuel Adesina Ademola, Afieharo Igbibia Michael, Ayodele Olukayode Iyun, Rotimi Opeyemi Aderibigbe, Odunayo Moronfoluwa Oluwatosin

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引用次数: 0

Abstract

Background: Infection in the patient with burn injury is a leading cause of morbidity and mortality worldwide. Clinicians in low- and middle-income countries are often left with no option other than to commence empirical antibiotics.

Objective: To determine the magnitude of infection in patients with burn injury, the sources of these infections, the prevalent microorganisms and their sensitivity pattern, and the sensitivity of the microorganisms to empirical therapy.

Materials and methods: This prospective observational study was conducted in a regional burn center in western Nigeria between October 2010 and March 2020.

Results: A total of 364 patients were included in the study, with males constituting 58.5% (213) of the patients and females 41.5% (151) of the patients. The median patient age was 22 years. Flame was the most common cause of burn injury (61.5% [n = 224]). The median total body surface area burn was 22%. The majority of the patients had a clinical diagnosis of infection (85.4% [n = 311]), with the burn wound (60.8%), respiratory tract (22.2%), and urinary tract (6.1%) constituting the clinical sources of the infection. The most prevalent causes of burn wound infection were Klebsiella pneumoniae (K pneumoniae) (30.2%), Staphylococcus aureus (S aureus) (24.3%), and Pseudomonas aeruginosa (P aeruginosa) (21.0%). All cultured bacteria with the exception of Citrobacter freundii were sensitive to amikacin, with K pneumoniae and S aureus being the most sensitive to it, and P. aeruginosa being more sensitive to ceftazidime. The most commonly prescribed empirical antibiotics were amikacin (20.3%) and levofloxacin (19.8%). The cultured organisms in burn injury patients with wound infection showed high sensitivity and specificity to empirical antibiotics therapy.

Conclusion: The results of this study indicate that the source of infection determines the most likely organism and its sensitivity profile.

本刊更多论文

烧伤患者的感染：来源、病原体、敏感性和经验性抗生素治疗的作用。

背景：在世界范围内，烧伤患者感染是发病率和死亡率的主要原因。低收入和中等收入国家的临床医生往往别无选择，只能开始使用经验性抗生素。目的：了解烧伤患者感染的程度、感染的来源、流行的微生物及其敏感型，以及微生物对经验治疗的敏感性。材料和方法：本前瞻性观察研究于2010年10月至2020年3月在尼日利亚西部的一个区域烧伤中心进行。结果：共纳入364例患者，其中男性213例，占58.5%，女性151例，占41.5%。患者年龄中位数为22岁。火焰是最常见的烧伤原因（61.5% [n = 224]）。中位体表面积烧伤为22%。大多数患者临床诊断为感染（85.4% [n = 311]），其中烧伤创面（60.8%）、呼吸道（22.2%）和泌尿道（6.1%）是临床感染源。烧伤创面感染最常见的原因是肺炎克雷伯菌（K肺炎菌）（30.2%）、金黄色葡萄球菌（S金黄色葡萄球菌）（24.3%）和铜绿假单胞菌（P铜绿假单胞菌）（21.0%）。除弗伦地柠檬酸杆菌外，其余培养菌均对阿米卡星敏感，其中肺炎K菌和金黄色葡萄球菌对阿米卡星最敏感，铜绿假单胞菌对头孢他啶最敏感。最常用的经验性抗生素是阿米卡星（20.3%）和左氧氟沙星（19.8%）。烧伤创面感染患者培养的微生物对经验性抗生素治疗具有较高的敏感性和特异性。结论：本研究结果表明，感染源决定了最可能的微生物及其敏感性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Wounds : a compendium of clinical research and practice 医学-皮肤病学

CiteScore

1.50

自引率

11.80%

发文量

审稿时长

6-12 weeks

期刊介绍： Wounds is the most widely read, peer-reviewed journal focusing on wound care and wound research. The information disseminated to our readers includes valuable research and commentaries on tissue repair and regeneration, biology and biochemistry of wound healing, and clinical management of various wound etiologies. Our multidisciplinary readership consists of dermatologists, general surgeons, plastic surgeons, vascular surgeons, internal medicine/family practitioners, podiatrists, gerontologists, researchers in industry or academia (PhDs), orthopedic surgeons, infectious disease physicians, nurse practitioners, and physician assistants. These practitioners must be well equipped to deal with a myriad of chronic wound conditions affecting their patients including vascular disease, diabetes, obesity, dermatological disorders, and more. Whether dealing with a traumatic wound, a surgical or non-skin wound, a burn injury, or a diabetic foot ulcer, wound care professionals turn to Wounds for the latest in research and practice in this ever-growing field of medicine.