Classification of Myelodysplastic, Myeloproliferative, and Myelodysplastic/Myeloproliferative Neoplasms: The Past, Present, and Future

IF 10.1 1区 医学 Q1 HEMATOLOGY
Daniel A. Arber, Attilio Orazi
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引用次数: 0

Abstract

With the recent publication of new classification systems of hematopoietic neoplasms, understanding how recognition of disease entities has occurred over time and the subsequent development of formal disease classifications is of importance. This review focuses on the early recognition of myeloid disorders, especially chronic myeloid disorders, and how clinical observations became associated with specific cytologic, histologic, immunophenotypic, and eventually genetic features. This combined approach to disease classification is of particular importance in the evaluation of chronic myeloid neoplasms and has resulted in the definition of clinicopathologic disease entities that allow for more customized treatment approaches. The constant incorporation of ever-increasing information related to these disorders illustrates that disease classification is a constantly evolving process that requires constant updates as we strive to better understand the disorders we diagnose and treat.
骨髓增生异常、骨髓增生性和骨髓增生异常/骨髓增生性肿瘤的分类:过去、现在和未来
随着造血肿瘤新分类系统的发表,了解疾病实体的识别是如何随着时间的推移而发生的,以及随后正式疾病分类的发展是很重要的。这篇综述的重点是髓系疾病的早期识别,特别是慢性髓系疾病,以及临床观察如何与特定的细胞学、组织学、免疫表型和最终的遗传特征相关联。这种疾病分类的综合方法在慢性髓系肿瘤的评估中特别重要,并导致临床病理疾病实体的定义,从而允许更多的定制治疗方法。不断纳入与这些疾病相关的不断增加的信息表明,疾病分类是一个不断发展的过程,需要不断更新,因为我们努力更好地了解我们诊断和治疗的疾病。
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来源期刊
CiteScore
15.70
自引率
3.90%
发文量
363
审稿时长
3-6 weeks
期刊介绍: The American Journal of Hematology offers extensive coverage of experimental and clinical aspects of blood diseases in humans and animal models. The journal publishes original contributions in both non-malignant and malignant hematological diseases, encompassing clinical and basic studies in areas such as hemostasis, thrombosis, immunology, blood banking, and stem cell biology. Clinical translational reports highlighting innovative therapeutic approaches for the diagnosis and treatment of hematological diseases are actively encouraged.The American Journal of Hematology features regular original laboratory and clinical research articles, brief research reports, critical reviews, images in hematology, as well as letters and correspondence.
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