Physical activity and lung cancer screening (PALS): feasibility randomised controlled trial of exercise and physical activity in lung cancer screening.

IF 5.8 2区医学 Q1 Medicine

Respiratory Research Pub Date : 2025-03-06 DOI:10.1186/s12931-025-03158-0

Asha Bonney, Catherine L Granger, Daniel Steinfort, Cameron Patrick, Henry M Marshall, Kwun M Fong, Renee Manser

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引用次数: 0

Abstract

Background: There is increasing evidence that screening provides a catalyst for behavioural change. Low physical activity (PA) levels are a potentially modifiable risk factor for developing lung cancer. This study aims to assess the feasibility and safety of a semi-supervised 8-week multi-modal exercise program to improve health-related quality of life and PA levels of participants of lung cancer screening.

Methods: Participants without lung cancer from a single Australian International Lung Screen Trial (ILST; NCT02871856) site were invited to this feasibility randomised controlled trial. Enrolled participants were randomised to usual care, written material, or a home-based exercise program (in addition to written material). Assessments occurred at baseline, 9 weeks, and 6 months.

Results: 75 participants were enrolled over a 3-month period in 2022 (consent rate of 67%). 43% of participants were female, median age 66 years old (IQR 62, 73). Of the 25 participants randomised to the home-based exercise program, 22 participants (88%) attended > 70% of weekly sessions. 99% (74/75) of study participants attended their 9-week and 6-month follow-up assessments.

Conclusions: This study confirms the feasibility and high compliance of delivering a semi-supervised 8-week multi-modal exercise program to participants of a lung cancer screening program. It was safe, with no adverse events.

Clinical trial registration: Australian Clinical Trials Register https://www.australianclinicaltrials.gov.au ACTRN12622001001785.

查看原文本刊更多论文

体育活动与肺癌筛查（PALS）：运动和体育活动在肺癌筛查中的可行性随机对照试验。

背景：越来越多的证据表明，筛查是行为改变的催化剂。低体力活动（PA）水平是患肺癌的一个潜在的可改变的危险因素。本研究旨在评估半监督的8周多模式运动计划的可行性和安全性，以改善肺癌筛查参与者的健康相关生活质量和PA水平。方法：来自澳大利亚国际肺筛查试验(ILST；NCT02871856)站点被邀请参加这项可行性随机对照试验。入组的参与者被随机分配到常规护理组、书面材料组或家庭锻炼组（除了书面材料外）。评估分别在基线、9周和6个月进行。结果：在2022年的3个月期间，75名参与者被招募（同意率为67%）。43%的参与者为女性，中位年龄66岁（IQR 62,73）。在随机分配到家庭锻炼计划的25名参与者中，22名参与者（88%）参加了每周锻炼的70%。99%（74/75）的研究参与者参加了9周和6个月的随访评估。结论：本研究证实了为肺癌筛查项目的参与者提供半监督的8周多模式运动计划的可行性和高依从性。它是安全的，没有不良反应。临床试验注册：澳大利亚临床试验注册https://www.australianclinicaltrials.gov.au ACTRN12622001001785。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Respiratory Research RESPIRATORY SYSTEM-

CiteScore

9.70

自引率

1.70%

发文量

314

审稿时长

4-8 weeks

期刊介绍： Respiratory Research publishes high-quality clinical and basic research, review and commentary articles on all aspects of respiratory medicine and related diseases. As the leading fully open access journal in the field, Respiratory Research provides an essential resource for pulmonologists, allergists, immunologists and other physicians, researchers, healthcare workers and medical students with worldwide dissemination of articles resulting in high visibility and generating international discussion. Topics of specific interest include asthma, chronic obstructive pulmonary disease, cystic fibrosis, genetics, infectious diseases, interstitial lung diseases, lung development, lung tumors, occupational and environmental factors, pulmonary circulation, pulmonary pharmacology and therapeutics, respiratory immunology, respiratory physiology, and sleep-related respiratory problems.