The role of radical cystectomy with orthotopic neobladder reconstruction in patients developing bladder cancer after prior radical prostatectomy, radiation therapy or BPH surgery.

IF 1.5 4区医学 Q3 UROLOGY & NEPHROLOGY

Urologia Internationalis Pub Date : 2025-03-06 DOI:10.1159/000545103

Nikolaos Pyrgidis, Yannic Volz, Sarah Takayama Fouladgar, Benedikt Ebner, Philipp Weinhold, Julian Marcon, Michael Chaloupka, Christian G Stief, Gerald Schulz, Patrick Keller

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引用次数: 0

Abstract

Introduction: Current evidence suggests that prior prostatic interventions, such as prostatectomy, radiation, or transurethral surgery may increase the risk of incontinence in patients undergoing radical cystectomy (RC) with ileal orthotopic neobladder reconstruction. We aimed to evaluate the short- and long-term complications, functional outcomes of neobladder reconstruction in patients undergoing RC after prior prostatic procedures.

Methods: We analyzed patients who underwent RC after prior prostatic intervention in our department from 2013-2022. A comparison was made between patients receiving neobladder reconstruction (ONB) versus ileal conduit, including propensity-score-matching for age and preoperative continence.

Results: We included 79 patients who underwent RC for bladder cancer after prior prostatic intervention. Of them, 43 (54%) patients had previously undergone BPH surgery, 29 (37%) radical prostatectomy and 7 (9%) prostate radiation therapy. An ileal conduit was performed in 62 (78%) cases. Patients presented similar baseline characteristics, perioperative complications, and quality of life after RC. Accordingly, after propensity-score-matching patients with ONB after prior prostatic intervention and patients who received ONB without prior prostatic intervention did not differ significantly in their baseline characteristics, perioperative complications and quality of life. 24% of patients without prior intervention reported incontinence, compared to 53% with prior prostatic intervention.

Conclusion: Neobladder reconstruction remains to be a feasible option in patients undergoing RC after prior prostatic intervention.

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来源期刊

Urologia Internationalis 医学-泌尿学与肾脏学

CiteScore

3.30

自引率

6.20%

发文量

审稿时长

3-8 weeks

期刊介绍： Concise but fully substantiated international reports of clinically oriented research into science and current management of urogenital disorders form the nucleus of original as well as basic research papers. These are supplemented by up-to-date reviews by international experts on the state-of-the-art of key topics of clinical urological practice. Essential topics receiving regular coverage include the introduction of new techniques and instrumentation as well as the evaluation of new functional tests and diagnostic methods. Special attention is given to advances in surgical techniques and clinical oncology. The regular publication of selected case reports represents the great variation in urological disease and illustrates treatment solutions in singular cases.