Long-lasting improvement of memory after targeted cognitive remediation in temporal epilepsy: A randomized control study

IF 2.8 4区医学 Q2 CLINICAL NEUROLOGY

Revue neurologique Pub Date : 2025-04-01 DOI:10.1016/j.neurol.2025.02.001

N. Forthoffer , L. Maillard , A. Thiriaux , M. Lemesle Martin , J.P. Vignal , H. Brissart

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引用次数: 0

Abstract

Background

Memory deficits are a major burden in temporal lobe epilepsy (TLE), contributing to the impaired quality of life of patients. Short- and long-term efficacy of memory remediation in TLE is still debated. The aim of our study was to assess the short- and long-term efficacy of a cognitive remediation program, COMETE (COgnitive Rehabilitation of MEmory in Temporal Epilepsy), targeting specifically episodic memory in patients with TLE.

Methods

In this prospective randomized single-blinded trial, patients from different French epilepsy centers were randomly assigned in a 2:4 ratio, via a computer-generated code, to receive remediation intervention or no intervention between neuropsychological assessments. Neuropsychologists assessing the cognitive performance at baseline, at immediate follow-up (3 months after baseline) and in long-term follow-up (10 to 12 months after baseline) were blinded to the intervention allocation.

Results

Sixty out of 66 included patients were randomized. Patients in the Remediation group significantly improved their performances in the subtests addressed by the program (verbal and non-verbal memory; P < 0.001 at 3 months and P < 0.001 at 10/12 months) while patients in the Control group did not. In verbal memory, 56% of the patients in the Remediation group normalized their performance in verbal memory learning score while 7% of the patients in the Control group did.

Conclusions

Cognitive remediation targeting memory is efficient at short and long term in temporal lobe epilepsy patients.

查看原文本刊更多论文

颞叶癫痫患者靶向认知修复后记忆的持久改善：一项随机对照研究。

背景：记忆缺陷是颞叶癫痫（TLE）患者的主要负担，导致患者生活质量下降。记忆修复在TLE中的短期和长期疗效仍存在争议。本研究的目的是评估认知修复项目COMETE（颞叶癫痫记忆认知康复）的短期和长期疗效，该项目专门针对颞叶癫痫患者的情景记忆。方法：在这项前瞻性随机单盲试验中，来自法国不同癫痫中心的患者通过计算机生成的代码以2:4的比例随机分配，在神经心理评估之间接受补救干预或不干预。神经心理学家在基线、即时随访（基线后3个月）和长期随访（基线后10至12个月）时评估认知表现，对干预分配不知情。结果：66例纳入的患者中有60例是随机的。修复组患者在该程序处理的子测试中的表现显著提高(言语和非言语记忆；结论：以记忆为目标的认知修复对颞叶癫痫患者具有短期和长期的疗效。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Revue neurologique 医学-临床神经学

CiteScore

4.80

自引率

0.00%

发文量

598

审稿时长

55 days

期刊介绍： The first issue of the Revue Neurologique, featuring an original article by Jean-Martin Charcot, was published on February 28th, 1893. Six years later, the French Society of Neurology (SFN) adopted this journal as its official publication in the year of its foundation, 1899. The Revue Neurologique was published throughout the 20th century without interruption and is indexed in all international databases (including Current Contents, Pubmed, Scopus). Ten annual issues provide original peer-reviewed clinical and research articles, and review articles giving up-to-date insights in all areas of neurology. The Revue Neurologique also publishes guidelines and recommendations. The Revue Neurologique publishes original articles, brief reports, general reviews, editorials, and letters to the editor as well as correspondence concerning articles previously published in the journal in the correspondence column.