Long-lasting improvement of memory after targeted cognitive remediation in temporal epilepsy: A randomized control study.

IF 2.8 4区医学 Q2 CLINICAL NEUROLOGY

Revue neurologique Pub Date : 2025-03-05 DOI:10.1016/j.neurol.2025.02.001

N Forthoffer, L Maillard, A Thiriaux, M Lemesle Martin, J P Vignal, H Brissart

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引用次数: 0

Abstract

Background: Memory deficits are a major burden in temporal lobe epilepsy (TLE), contributing to the impaired quality of life of patients. Short- and long-term efficacy of memory remediation in TLE is still debated. The aim of our study was to assess the short- and long-term efficacy of a cognitive remediation program, COMETE (COgnitive Rehabilitation of MEmory in Temporal Epilepsy), targeting specifically episodic memory in patients with TLE.

Methods: In this prospective randomized single-blinded trial, patients from different French epilepsy centers were randomly assigned in a 2:4 ratio, via a computer-generated code, to receive remediation intervention or no intervention between neuropsychological assessments. Neuropsychologists assessing the cognitive performance at baseline, at immediate follow-up (3months after baseline) and in long-term follow-up (10 to 12months after baseline) were blinded to the intervention allocation.

Results: Sixty out of 66 included patients were randomized. Patients in the Remediation group significantly improved their performances in the subtests addressed by the program (verbal and non-verbal memory; P<0.001 at 3months and P<0.001 at 10/12months) while patients in the Control group did not. In verbal memory, 56% of the patients in the Remediation group normalized their performance in verbal memory learning score while 7% of the patients in the Control group did.

Conclusions: Cognitive remediation targeting memory is efficient at short and long term in temporal lobe epilepsy patients.

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来源期刊

Revue neurologique 医学-临床神经学

CiteScore

4.80

自引率

0.00%

发文量

598

审稿时长

55 days

期刊介绍： The first issue of the Revue Neurologique, featuring an original article by Jean-Martin Charcot, was published on February 28th, 1893. Six years later, the French Society of Neurology (SFN) adopted this journal as its official publication in the year of its foundation, 1899. The Revue Neurologique was published throughout the 20th century without interruption and is indexed in all international databases (including Current Contents, Pubmed, Scopus). Ten annual issues provide original peer-reviewed clinical and research articles, and review articles giving up-to-date insights in all areas of neurology. The Revue Neurologique also publishes guidelines and recommendations. The Revue Neurologique publishes original articles, brief reports, general reviews, editorials, and letters to the editor as well as correspondence concerning articles previously published in the journal in the correspondence column.