Third Artificial Urinary Sphincter Cuff Placement Following Two Failures in Males: A Real-World Multicenter Study.

IF 1.8 3区 医学 Q3 UROLOGY & NEPHROLOGY
Francois Meyer, Juliette Cotte, Lucas Bento, Guillaume Nicaud, Hubert Werth, Alexandre Dubois, Christian Saussine, François Desgranchamps, Emmanuel Chartier-Kastler, Xavier Gamé, Jean-François Hermieu, Jean-Nicolas Cornu, Benoît Peyronnet
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引用次数: 0

Abstract

Introduction: The reoperation rate for artificial urinary sphincters (AUS) in men is about 25%, with poorer survival rates when reimplantation occurs after urethral erosion or infection. Data on the outcomes of second AUS implants are rare, and no data exist for third AUS implants. We aimed to evaluate the functional and survival outcomes of a third AUS after two previous explantations.

Methods: The records of all patients implanted with a third AUS between 2006 and 2023 in seven French university hospitals were reviewed retrospectively. Only AUS implants following two previous AUS cuff explantations or revisions were included. The primary endpoint was the reoperation-free survival of the third AUS. Secondary endpoints included functional outcomes at 6 months and at the last follow-up, and overall functional outcomes after possible subsequent AUS implants, as well as reoperations.

Results: A total of 75 patients were included. Early complications occurred in 16.7% of patients. Median follow-up was 11 months (1-122), 28 explantations were required (37.3%). The 5-year reoperation-free survival rate was 34.8%. The only significant predictive factor for explantation was smoking. At 6 months, 66.2% of patients were socially continent (0-1 protection per day), 10.8% were improved, and 23% were unchanged or worsened. At the last follow-up of the third AUS, these results were 40%, 5.3%, and 54.7%, respectively. However, at the last overall follow-up (median 12 months, 1-183), social continence was 54.8%, improvement 9.6%, and failure 35.6%, with 23 patients (30.7%) receiving a fourth or fifth AUS.

Conclusion: Early functional outcomes of a third AUS are similar to primary AUS, but survival rates and late functional outcomes are inferior. Predictive factors for outcomes were related to patients, not the surgery itself. A third AUS may be suitable for motivated patients with limited therapeutic options. Further studies are needed to refine patient selection and assess the impact of reimplantation techniques on outcomes.

男性两次失败后的第三次人工尿道括约肌袖带置入术:一项真实世界多中心研究。
简介:男性人工尿道括约肌(AUS)再手术率约为25%,尿道糜烂或感染后再植入术生存率较低。关于第二次AUS植入的结果的数据很少,而关于第三次AUS植入的数据则没有。我们的目的是评估前两次解释后第三例AUS的功能和生存结果。方法:回顾性分析2006年至2023年间法国7所大学医院所有植入第三个AUS的患者的记录。仅包括之前两次AUS袖带解释或修复后的AUS植入物。主要终点是第三例AUS的无再手术生存期。次要终点包括6个月和最后一次随访时的功能结果,以及可能的后续AUS植入和再手术后的总体功能结果。结果:共纳入75例患者。16.7%的患者出现早期并发症。中位随访时间为11个月(1-122),需要28次解释(37.3%)。5年无再手术生存率为34.8%。唯一有意义的外植体预测因素是吸烟。在6个月时,66.2%的患者的社交无障碍(每天0-1个保护),10.8%的患者得到改善,23%的患者没有变化或恶化。在第三次AUS最后随访时,这些结果分别为40%,5.3%和54.7%。然而,在最后一次总体随访(中位12个月,1-183)中,社交控制为54.8%,改善为9.6%,失败为35.6%,其中23例患者(30.7%)接受了第四或第五次AUS。结论:第三例AUS的早期功能结局与原发性AUS相似,但生存率和晚期功能结局较差。结果的预测因素与患者有关,而与手术本身无关。第三种AUS可能适用于治疗选择有限的积极患者。需要进一步的研究来完善患者选择和评估再植技术对结果的影响。
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来源期刊
Neurourology and Urodynamics
Neurourology and Urodynamics 医学-泌尿学与肾脏学
CiteScore
4.30
自引率
10.00%
发文量
231
审稿时长
4-8 weeks
期刊介绍: Neurourology and Urodynamics welcomes original scientific contributions from all parts of the world on topics related to urinary tract function, urinary and fecal continence and pelvic floor function.
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