{"title":"Oxidative stress markers in occupational noise exposure: a systematic review and meta-analysis.","authors":"Soheil Rahmati, Sogand Sadeghi, Mahmood Moosazadeh","doi":"10.1007/s00420-025-02131-0","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Exposure to occupational noise could lead to detrimental health outcomes by inducing oxidative stress mechanisms. In this study, we sought to investigate the impact of occupational noise exposure on serum and/or plasma levels of oxidative stress markers.</p><p><strong>Methods: </strong>We performed a thorough search across PubMed, Web of Science, and SCOPUS for articles comparing oxidative stress markers, including malondialdehyde (MDA) and/or superoxide dismutase (SOD) and/or glutathione peroxidase (GPx) and/or total antioxidant capacity (TAC), in individuals occupationally exposed to high noise and unexposed controls. The random-effects model was applied to determine the standardized mean difference (SMD) and the associated 95% confidence interval (CI).</p><p><strong>Results: </strong>Seven primary studies were included. The analysis encompassed a total of 989 workers, including 537 individuals exposed to occupational noise levels exceeding 85 dB and 452 workers exposed to noise below 85 dB. Meta-analysis indicated that workers with high noise exposure exhibited significantly elevated TAC levels (SMD, 2.74; 95% CI: 1.87 to 3.61; p = 0.00; I<sup>2</sup> = 88.75%) and SOD levels (SMD, 0.90; 95% CI, 0.47 to 1.33; p = 0.00; I<sup>2</sup> = 69.32%), while no significant differences were observed among the groups regarding MDA levels (SMD, 1.03; 95% CI, -0.12 to 2.18; p = 0.08; I<sup>2</sup> = 97.30%) and GPx levels (SMD, 1.35; 95% CI, -0.41 to 3.11; p = 0.13; I<sup>2</sup> = 98.63%).</p><p><strong>Conclusion: </strong>Our results suggest that TAC and SOD levels are elevated in workers exposed to high noise, potentially indicating heightened free radical production. However, no significant differences were found in MDA and GPx levels, warranting further investigation. Early detection and intervention may help reduce the harmful health impacts of noise exposure.</p>","PeriodicalId":13761,"journal":{"name":"International Archives of Occupational and Environmental Health","volume":" ","pages":"155-167"},"PeriodicalIF":2.6000,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Archives of Occupational and Environmental Health","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00420-025-02131-0","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/3/6 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Exposure to occupational noise could lead to detrimental health outcomes by inducing oxidative stress mechanisms. In this study, we sought to investigate the impact of occupational noise exposure on serum and/or plasma levels of oxidative stress markers.
Methods: We performed a thorough search across PubMed, Web of Science, and SCOPUS for articles comparing oxidative stress markers, including malondialdehyde (MDA) and/or superoxide dismutase (SOD) and/or glutathione peroxidase (GPx) and/or total antioxidant capacity (TAC), in individuals occupationally exposed to high noise and unexposed controls. The random-effects model was applied to determine the standardized mean difference (SMD) and the associated 95% confidence interval (CI).
Results: Seven primary studies were included. The analysis encompassed a total of 989 workers, including 537 individuals exposed to occupational noise levels exceeding 85 dB and 452 workers exposed to noise below 85 dB. Meta-analysis indicated that workers with high noise exposure exhibited significantly elevated TAC levels (SMD, 2.74; 95% CI: 1.87 to 3.61; p = 0.00; I2 = 88.75%) and SOD levels (SMD, 0.90; 95% CI, 0.47 to 1.33; p = 0.00; I2 = 69.32%), while no significant differences were observed among the groups regarding MDA levels (SMD, 1.03; 95% CI, -0.12 to 2.18; p = 0.08; I2 = 97.30%) and GPx levels (SMD, 1.35; 95% CI, -0.41 to 3.11; p = 0.13; I2 = 98.63%).
Conclusion: Our results suggest that TAC and SOD levels are elevated in workers exposed to high noise, potentially indicating heightened free radical production. However, no significant differences were found in MDA and GPx levels, warranting further investigation. Early detection and intervention may help reduce the harmful health impacts of noise exposure.
期刊介绍：
International Archives of Occupational and Environmental Health publishes Editorials, Review Articles, Original Articles, and Letters to the Editor. It welcomes any manuscripts dealing with occupational or ambient environmental problems, with a special interest in research at the interface of occupational health and clinical medicine. The scope ranges from Biological Monitoring to Dermatology, from Fibers and Dust to Human Toxicology, from Nanomaterials and Ultra-fine Dust to Night- and Shift Work, from Psycho-mental Distress and Burnout to Vibrations. A complete list of topics can be found on the right-hand side under For authors and editors.
In addition, all papers should be based on present-day standards and relate to:
-Clinical and epidemiological studies on morbidity and mortality
-Clinical epidemiological studies on the parameters relevant to the estimation of health risks
-Human experimental studies on environmental health effects. Animal experiments are only acceptable if relevant to pathogenic aspects.
-Methods for studying the topics mentioned above.
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