Association Between Polygenic Risk and Symptom Severity Change After Cognitive Behavioral Therapy for Obsessive-Compulsive Disorder

IF 1.6 3区 医学 Q3 GENETICS & HEREDITY
Julia Bäckman, John Wallert, Matthew Halvorsen, Bjorn Roelstraete, Elles de Schipper, Nora I. Strom, Thorstein Olsen Eide, Kira D. Höffler, Manuel Mattheisen, Bjarne Hansen, Gerd Kvale, Kristen Hagen, Jan Haavik, Nordic OCD and Related Disorders Consortium (NORDiC), David Mataix-Cols, Christian Rück, James J. Crowley
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引用次数: 0

Abstract

A large proportion of patients undergoing cognitive behavior therapy (CBT) for obsessive-compulsive disorder (OCD) do not respond sufficiently to treatment. Identifying predictors for change in symptom severity after treatment could inform clinical decision-making, allow for better-tailored interventions, and avoid treatment failure. Prior research on predictors for treatment response has, however, yielded inconsistent findings with limited clinical utility. Here, we investigated the predictive power of nine polygenic risk scores (PRSs) for psychiatric and cognitive traits in 1598 OCD patients (1167 adults and 431 children/adolescents) treated with CBT in Sweden and Norway. We fitted linear mixed models adjusted for age, sex, genotyping batch, and the first five ancestry PCs to estimate associations between PRS and symptom severity change from pre- to post-treatment. The PRS for schizophrenia showed a modestly significant association with symptom change (β = 0.013, p = 0.04, R 2 = 0.10), indicating that a higher PRS for schizophrenia was associated with a smaller decrease in symptom severity. No other PRS were significantly associated with the outcome. While these results await replication and expansion, current PRS for psychiatric and cognitive phenotypes do not seem to contribute meaningfully to symptom severity change in CBT for OCD.

认知行为治疗后强迫症多基因风险与症状严重程度改变的关系
很大一部分接受认知行为疗法(CBT)治疗强迫症(OCD)的患者对治疗没有足够的反应。确定治疗后症状严重程度变化的预测因素可以为临床决策提供信息,允许更好地定制干预措施,并避免治疗失败。然而,先前对治疗反应预测因子的研究结果不一致,临床应用有限。在此,我们调查了瑞典和挪威接受CBT治疗的1598名强迫症患者(1167名成人和431名儿童/青少年)的9个多基因风险评分(prs)对精神和认知特征的预测能力。我们拟合了线性混合模型,调整了年龄、性别、基因分型批次和前五个祖先pc,以估计治疗前后PRS与症状严重程度变化之间的关系。精神分裂症患者的PRS与症状变化呈中度显著相关(β = 0.013, p = 0.04, R2 = 0.10),表明精神分裂症患者的PRS越高,症状严重程度的降低越小。没有其他PRS与结果显著相关。虽然这些结果有待复制和扩展,但目前精神和认知表型的PRS似乎对CBT治疗强迫症的症状严重程度变化没有意义。
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来源期刊
CiteScore
5.90
自引率
7.10%
发文量
40
审稿时长
4-8 weeks
期刊介绍: Neuropsychiatric Genetics, Part B of the American Journal of Medical Genetics (AJMG) , provides a forum for experimental and clinical investigations of the genetic mechanisms underlying neurologic and psychiatric disorders. It is a resource for novel genetics studies of the heritable nature of psychiatric and other nervous system disorders, characterized at the molecular, cellular or behavior levels. Neuropsychiatric Genetics publishes eight times per year.
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