Comparative Analysis of Lamina Parameters in Nonglaucomatous Eyes With and Without Pseudoexfoliation Syndrome

IF 4.1 1区医学 Q1 OPHTHALMOLOGY

American Journal of Ophthalmology Pub Date : 2025-03-05 DOI:10.1016/j.ajo.2025.02.041

YOUNG HOON JUNG , JOON MO KIM , EUN JI LEE , TEA-WOO KIM , SO YOUNG HAN , YONGWOO LEE , JI EUN SONG

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引用次数: 0

Abstract

Objective

To compare lamina cribrosa (LC) parameters in nonglaucomatous eyes with pseudoexfoliation syndrome (PXFS) and healthy control eyes to assess structural alterations that may contribute to early glaucoma pathophysiology.

Design

Retrospective, cross-sectional study.

Participants

Fifty eyes with non-glaucomatous PXFS and 50 healthy, age-matched control eyes.

Methods

All participants underwent spectral-domain optical coherence tomography with enhanced-depth imaging. LC parameters were measured at the superior mid-peripheral, central, and inferior mid-peripheral regions. Comparisons between groups were assessed with paired t-tests for continuous data and the McNemar test for categorical data. Mixed effects model analysis was utilized to identify factors associated with lamina cribrosa thickness (LCT).

Main Outcome Measures

Measurements of LCT, lamina cribrosa curvature depth (LCCD), curvature index (LCCI), and prelaminar tissue thickness (PLTT).

Results

Eyes with PXFS exhibited significantly thinner LCT than controls across all regions: superior mid-peripheral (163.85 ± 39.13 µm vs. 222.18 ± 38.03 µm), central (172.95 ± 40.63 µm vs. 220.17 ± 51.77 µm), and inferior mid-peripheral (165.58 ± 35.18 µm vs. 217.73 ± 44.00 µm). No significant differences were observed in PLTT, LCCD and LCCI between the 2 groups. Multivariable mixed effects model analysis identified the presence of PXFS (β = -50.687) as an independent factor associated with LCT.

Conclusion

PXFS eyes show significant LC thinning, potentially representing early structural changes preceding glaucoma. Monitoring LC parameters in PXFS eyes may facilitate early detection of patients at risk of disease progression.

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来源期刊

American Journal of Ophthalmology 医学-眼科学

CiteScore

9.20

自引率

7.10%

发文量

406

审稿时长

36 days

期刊介绍： The American Journal of Ophthalmology is a peer-reviewed, scientific publication that welcomes the submission of original, previously unpublished manuscripts directed to ophthalmologists and visual science specialists describing clinical investigations, clinical observations, and clinically relevant laboratory investigations. Published monthly since 1884, the full text of the American Journal of Ophthalmology and supplementary material are also presented online at www.AJO.com and on ScienceDirect. The American Journal of Ophthalmology publishes Full-Length Articles, Perspectives, Editorials, Correspondences, Books Reports and Announcements. Brief Reports and Case Reports are no longer published. We recommend submitting Brief Reports and Case Reports to our companion publication, the American Journal of Ophthalmology Case Reports. Manuscripts are accepted with the understanding that they have not been and will not be published elsewhere substantially in any format, and that there are no ethical problems with the content or data collection. Authors may be requested to produce the data upon which the manuscript is based and to answer expeditiously any questions about the manuscript or its authors.