The wound healing effects of linearly polarized irradiation in photobiomodulation.

IF 2.7 3区 化学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY
Photochemical & Photobiological Sciences Pub Date : 2025-03-01 Epub Date: 2025-03-07 DOI:10.1007/s43630-025-00696-w
You-Rim Park, Yoo-Kyoung Shin, Joo Beom Eom
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引用次数: 0

Abstract

We report the fabrication of a polarization-based photobiomodulation (PBM) system and its performance on wound healing effects. The light source for PBM was a 625 nm LED and two different linear polarizations (P-wave and S-wave) were generated using the wire grid linear polarizers. To confirm the effect of PBM on polarization, wounds were created on hairless mice, and the healing process was compared. The light source conditions for comparison were control, two linearly polarized light, and unpolarized light. The light irradiation conditions for each group were based on the energy settings (energy 18 J/cm2, power density 30 mW/cm2, exposure time 600 sec) commonly used in LED masks. After creating the wound, the light was irradiated only once. To confirm the wound healing effect over time, it was evaluated through wound surface area measurements, self-made optical coherence tomography images, and histological images. In the group irradiated with S-wave polarized light, the percentage from the initial wound size was reduced to 70.73%, and the epithelial tongue ratio reached 58.36% on day 7 after PBM, indicating the fastest recovery. In this way, the potential of a new product that can increase the effect of wound healing or skin regeneration by adjusting the polarization state without irradiating high energy was confirmed.

线偏振辐射在光生物调节中的伤口愈合作用。
我们报道了一种基于偏振的光生物调节(PBM)系统的制备及其对伤口愈合效果的影响。PBM的光源为625 nm LED,利用线栅线偏振器产生两种不同的线偏振(p波和s波)。为了证实PBM对极化的影响,我们在无毛小鼠身上制造了伤口,并比较了愈合过程。比较的光源条件为对照、双线偏振光和非偏振光。各组的光照条件均基于LED掩模常用的能量设置(能量18 J/cm2,功率密度30 mW/cm2,曝光时间600秒)。在造成伤口后,光只照射一次。为了确认伤口随时间的愈合效果,我们通过伤口表面积测量、自制光学相干断层扫描图像和组织学图像来评估伤口愈合效果。s波偏振光照射组,创面大小恢复率降至70.73%,上皮舌在PBM后第7天恢复率达到58.36%,恢复速度最快。通过这种方式,证实了一种新产品的潜力,该产品可以通过调节极化状态来增加伤口愈合或皮肤再生的效果,而无需照射高能量。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Photochemical & Photobiological Sciences
Photochemical & Photobiological Sciences 生物-生化与分子生物学
CiteScore
5.60
自引率
6.50%
发文量
201
审稿时长
2.3 months
期刊介绍: A society-owned journal publishing high quality research on all aspects of photochemistry and photobiology.
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