{"title":"Neurexin-3 is Elevated and Associated with Cognition Status and 4-Hydroxynonenal in Bipolar Disorder.","authors":"Guguloth Sudhakar, Hanumanthappa Nandeesha, Vikas Menon, Kothandan Saravanan","doi":"10.1177/09727531251322019","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Alteration in synaptic plasticity and oxidative stress is involved in the pathogenesis of bipolar disorder (BD).</p><p><strong>Purpose: </strong>The objectives of the study were to analyse neurexin-3 and 4-hydroxynonenal (4-HNE) levels in BD and their relation with cognitive scores and severity of the disease.</p><p><strong>Methods: </strong>Eighty-four BD patients and 84 healthy volunteers were enrolled. Neurexin-3 and 4-HNE were analysed by enzyme-linked immunosorbent assay (ELISA). Cognitive scores were determined using Addenbrooke's Cognitive Examination III (ACE-III) scores.</p><p><strong>Results: </strong>4-HNE (<i>p</i> < .001) and neurexin-3 (<i>p</i> < .001) were higher in BD cases in comparison with controls. 4-HNE was positively related to neurexin-3 (<i>p</i> = .048). Neurexin-3 was related to the total ACE-III score (<i>p</i> = .029), attention (<i>p</i> = .040) and fluency (<i>p</i> = .026) scores in BD cases. When multivariate analysis was done, neurexin-3 was related to ACE-III score in BD (<i>p</i> = .005).</p><p><strong>Conclusion: </strong>We conclude that neurexin-3 is increased and associated with 4-HNE and cognitive dysfunction in BD.</p>","PeriodicalId":7921,"journal":{"name":"Annals of Neurosciences","volume":" ","pages":"09727531251322019"},"PeriodicalIF":1.8000,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11881091/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annals of Neurosciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1177/09727531251322019","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Alteration in synaptic plasticity and oxidative stress is involved in the pathogenesis of bipolar disorder (BD).
Purpose: The objectives of the study were to analyse neurexin-3 and 4-hydroxynonenal (4-HNE) levels in BD and their relation with cognitive scores and severity of the disease.
Methods: Eighty-four BD patients and 84 healthy volunteers were enrolled. Neurexin-3 and 4-HNE were analysed by enzyme-linked immunosorbent assay (ELISA). Cognitive scores were determined using Addenbrooke's Cognitive Examination III (ACE-III) scores.
Results: 4-HNE (p < .001) and neurexin-3 (p < .001) were higher in BD cases in comparison with controls. 4-HNE was positively related to neurexin-3 (p = .048). Neurexin-3 was related to the total ACE-III score (p = .029), attention (p = .040) and fluency (p = .026) scores in BD cases. When multivariate analysis was done, neurexin-3 was related to ACE-III score in BD (p = .005).
Conclusion: We conclude that neurexin-3 is increased and associated with 4-HNE and cognitive dysfunction in BD.
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