Ultrasensitive detection of doxycycline enabled by oxygen vacancy modulated TiO2 nanotubes

IF 5.3 2区化学 Q1 CHEMISTRY, ANALYTICAL

Microchimica Acta Pub Date : 2025-03-07 DOI:10.1007/s00604-025-07072-6

Juan Gao, Sen Yang, Chen Xu, Zerui Dong, SiZhu Chen, Lingcheng Zheng, Leilei Lan, Gang He

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Abstract

TiO₂ nanotubes rich in oxygen vacancies (Ov), which were successfully fabricated on Ti foils, were used as the working electrode of a photoelectrochemical (PEC) sensor. The TiO₂ nanotube electrode optimized with abundant Ov demonstrated a remarkable photocurrent density of 1.03 mA/cm², which is approximately 2.9 times higher than that of the TiO₂ nanotube electrode. When applied to the detection of DOC, this electrode exhibited a wide linear detection range spanning from 0.1 to 100 μM and achieved an exceptionally low detection limit of 0.043 μM with a signal-to-noise ratio of 3. Furthermore, comparative experiments indicated that the Ov-enriched TiO₂ nanotube electrode exhibited excellent anti-interference capabilities and long-term stability, ensuring the accuracy and reliability of the detection outcomes. The superior detection performance is primarily attributed to two aspects: on one hand, Ov act as electron traps, facilitating the capture and transfer of photogenerated electrons, effectively prolonging the lifetime of these carriers; on the other hand, Ov also serves as active sites, enhancing the adsorption of DOC molecules and reaction kinetics, further amplifying the detection signal. This work offers a theoretical and experimental groundwork for the rapid monitoring of residual antibiotics.

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来源期刊

Microchimica Acta 化学-分析化学

CiteScore

9.80

自引率

5.30%

发文量

410

审稿时长

2.7 months

期刊介绍： As a peer-reviewed journal for analytical sciences and technologies on the micro- and nanoscale, Microchimica Acta has established itself as a premier forum for truly novel approaches in chemical and biochemical analysis. Coverage includes methods and devices that provide expedient solutions to the most contemporary demands in this area. Examples are point-of-care technologies, wearable (bio)sensors, in-vivo-monitoring, micro/nanomotors and materials based on synthetic biology as well as biomedical imaging and targeting.