Optical Fiber Volatile Organic Compound Vapor Sensor With ppb Detectivity for Breath Biomonitoring

IF 4.3 2区综合性期刊 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC

IEEE Sensors Journal Pub Date : 2025-01-15 DOI:10.1109/JSEN.2025.3527765

Eleni Grantzioti;Stavros Pissadakis;Maria Konstantaki

{"title":"Optical Fiber Volatile Organic Compound Vapor Sensor With ppb Detectivity for Breath Biomonitoring","authors":"Eleni Grantzioti;Stavros Pissadakis;Maria Konstantaki","doi":"10.1109/JSEN.2025.3527765","DOIUrl":null,"url":null,"abstract":"The accurate monitoring of volatile organic compounds (VOCs) at low detection limits is critical for biomedical applications, as many VOCs serve as biomarkers for early disease detection and environmental exposure to harmful substances. This study presents the development and performance evaluation of a compact, easily produced, and low-cost, optical fiber sensor (OFS) for the detection of VOCs at parts per billion (ppb) levels. A 32-<inline-formula> <tex-math>$\\mu $ </tex-math></inline-formula>m cavity formed at the end face of a standard optical fiber, using a commercially available photopolymerizable resin, acts as a sensing Fabry-Perot (FP) interferometer registering the presence of methanol, ethanol, and isopropanol vapors with distinctive temporal and spectral response. A clear correlation between the molar mass of the examined compounds and the recorded temporal/refractive response of the sensor is established. The performance of the sensor was demonstrated in the detection of 200 ppb of methanol, while a potential limit of detection (LOD) for methanol vapor was estimated of the order of 1 ppb. Preliminary experiments in exhaled breath monitoring confirmed the ability of the sensor to perform breath alcohol content (BrAC) measurements.","PeriodicalId":447,"journal":{"name":"IEEE Sensors Journal","volume":"25 5","pages":"8224-8229"},"PeriodicalIF":4.3000,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"IEEE Sensors Journal","FirstCategoryId":"103","ListUrlMain":"https://ieeexplore.ieee.org/document/10843142/","RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENGINEERING, ELECTRICAL & ELECTRONIC","Score":null,"Total":0}

引用次数: 0

Abstract

The accurate monitoring of volatile organic compounds (VOCs) at low detection limits is critical for biomedical applications, as many VOCs serve as biomarkers for early disease detection and environmental exposure to harmful substances. This study presents the development and performance evaluation of a compact, easily produced, and low-cost, optical fiber sensor (OFS) for the detection of VOCs at parts per billion (ppb) levels. A 32-

$\mu $

m cavity formed at the end face of a standard optical fiber, using a commercially available photopolymerizable resin, acts as a sensing Fabry-Perot (FP) interferometer registering the presence of methanol, ethanol, and isopropanol vapors with distinctive temporal and spectral response. A clear correlation between the molar mass of the examined compounds and the recorded temporal/refractive response of the sensor is established. The performance of the sensor was demonstrated in the detection of 200 ppb of methanol, while a potential limit of detection (LOD) for methanol vapor was estimated of the order of 1 ppb. Preliminary experiments in exhaled breath monitoring confirmed the ability of the sensor to perform breath alcohol content (BrAC) measurements.

查看原文本刊更多论文

用于呼吸生物监测的ppb探测光纤挥发性有机化合物蒸汽传感器

在低检测限下准确监测挥发性有机化合物（VOCs）对于生物医学应用至关重要，因为许多VOCs可作为早期疾病检测和有害物质环境暴露的生物标志物。本研究介绍了一种紧凑、易于生产、低成本的光纤传感器（OFS）的开发和性能评估，用于检测十亿分之一（ppb）水平的VOCs。在标准光纤的端面形成一个32 μ m的空腔，使用市售的光聚合树脂，作为传感法布里-珀罗（FP）干涉仪，记录甲醇、乙醇和异丙醇蒸气的存在，具有独特的时间和光谱响应。在所检测化合物的摩尔质量和传感器记录的时间/折射响应之间建立了明确的相关性。传感器的性能在200 ppb甲醇的检测中得到了证明，而甲醇蒸气的潜在检测限（LOD）估计为1 ppb的数量级。呼气监测的初步实验证实了传感器进行呼气酒精含量（BrAC）测量的能力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

IEEE Sensors Journal 工程技术-工程：电子与电气

CiteScore

7.70

自引率

14.00%

发文量

2058

审稿时长

5.2 months

期刊介绍： The fields of interest of the IEEE Sensors Journal are the theory, design , fabrication, manufacturing and applications of devices for sensing and transducing physical, chemical and biological phenomena, with emphasis on the electronics and physics aspect of sensors and integrated sensors-actuators. IEEE Sensors Journal deals with the following: -Sensor Phenomenology, Modelling, and Evaluation -Sensor Materials, Processing, and Fabrication -Chemical and Gas Sensors -Microfluidics and Biosensors -Optical Sensors -Physical Sensors: Temperature, Mechanical, Magnetic, and others -Acoustic and Ultrasonic Sensors -Sensor Packaging -Sensor Networks -Sensor Applications -Sensor Systems: Signals, Processing, and Interfaces -Actuators and Sensor Power Systems -Sensor Signal Processing for high precision and stability (amplification, filtering, linearization, modulation/demodulation) and under harsh conditions (EMC, radiation, humidity, temperature); energy consumption/harvesting -Sensor Data Processing (soft computing with sensor data, e.g., pattern recognition, machine learning, evolutionary computation; sensor data fusion, processing of wave e.g., electromagnetic and acoustic; and non-wave, e.g., chemical, gravity, particle, thermal, radiative and non-radiative sensor data, detection, estimation and classification based on sensor data) -Sensors in Industrial Practice