Packaged GaN HEMT biosensor and handheld system for brain injury detection

IF 3.5 2区物理与天体物理 Q2 PHYSICS, APPLIED

Applied Physics Letters Pub Date : 2025-03-06 DOI:10.1063/5.0248100

Rajiv Thakur, Anil Kumar Saini, Nikhil Suri, Dheeraj Kumar Kharbanda, Rajeev Taliyan, Nidhi Chaturvedi

引用次数: 0

Abstract

In this Letter, an extended pad packaged GaN HEMT-based biosensing system has been reported for the detection of US Food and Drug Administration-approved ubiquitin-C-terminal-hydrolase-L1 and glial fibrillary acidic protein and Scandinavian Neurotrauma Committee-recommended S100B brain injury biomarkers in clinically relevant concentration ranges. The work is an extension of our preliminary reported work on the noninvasive detection of traumatic brain injury biomarkers using saliva [R. Thakur, IEEE Sens. J. 24(3), 2313 (2023)]. A very high sensitivity of 0.58 mA/ng/ml with good linearity (Adj. R2 = 0.99) was observed for the detection of S100B with a response time of less than 15 s. The platform offers a shelf life of four weeks with minute degradation of −3.08% and −4.66% in its stability and reactivity. The developed biosensing platform shows great potential for its deployment in real-time application areas due to its high sensitivity, good shelf life, and fast detection time.

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来源期刊

Applied Physics Letters 物理-物理：应用

CiteScore

6.40

自引率

10.00%

发文量

1821

审稿时长

1.6 months

期刊介绍： Applied Physics Letters (APL) features concise, up-to-date reports on significant new findings in applied physics. Emphasizing rapid dissemination of key data and new physical insights, APL offers prompt publication of new experimental and theoretical papers reporting applications of physics phenomena to all branches of science, engineering, and modern technology. In addition to regular articles, the journal also publishes invited Fast Track, Perspectives, and in-depth Editorials which report on cutting-edge areas in applied physics. APL Perspectives are forward-looking invited letters which highlight recent developments or discoveries. Emphasis is placed on very recent developments, potentially disruptive technologies, open questions and possible solutions. They also include a mini-roadmap detailing where the community should direct efforts in order for the phenomena to be viable for application and the challenges associated with meeting that performance threshold. Perspectives are characterized by personal viewpoints and opinions of recognized experts in the field. Fast Track articles are invited original research articles that report results that are particularly novel and important or provide a significant advancement in an emerging field. Because of the urgency and scientific importance of the work, the peer review process is accelerated. If, during the review process, it becomes apparent that the paper does not meet the Fast Track criterion, it is returned to a normal track.