Adaptation of the Spalax galili transcriptome to hypoxia may underlie the complex phenotype featuring longevity and cancer resistance.

IF 4.1 Q2 GERIATRICS & GERONTOLOGY
Gesa Poetzsch, Luca Jelacic, Leon Dammer, Sören Lukas Hellmann, Michelle Balling, Miguel Andrade-Navarro, Aaron Avivi, Imad Shams, Anne Bicker, Thomas Hankeln
{"title":"Adaptation of the Spalax galili transcriptome to hypoxia may underlie the complex phenotype featuring longevity and cancer resistance.","authors":"Gesa Poetzsch, Luca Jelacic, Leon Dammer, Sören Lukas Hellmann, Michelle Balling, Miguel Andrade-Navarro, Aaron Avivi, Imad Shams, Anne Bicker, Thomas Hankeln","doi":"10.1038/s41514-025-00206-3","DOIUrl":null,"url":null,"abstract":"<p><p>In the subterranean rodent (Nanno)spalax galili, evolutionary adaptation to hypoxia is correlated with longevity and tumor resistance. Adapted gene-regulatory networks of Spalax might pinpoint strategies to maintain health in humans. Comparing liver, kidney and spleen transcriptome data from Spalax and rat at hypoxia and normoxia, we identified differentially expressed gene pathways common to multiple organs in both species. Body-wide interspecies differences affected processes like cell death, antioxidant defense, DNA repair, energy metabolism, immune response and angiogenesis, which may play a crucial role in Spalax's adaptation to environmental hypoxia. In all organs, transcription of genes for genome stability maintenance and DNA repair was elevated in Spalax versus rat, accompanied by lower expression of aerobic energy metabolism and proinflammatory genes. These transcriptomic changes might account for the extraordinary lifespan of Spalax and its cancer resistance. The identified gene networks present candidates for further investigating the molecular basis underlying the complex Spalax phenotype.</p>","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"11 1","pages":"16"},"PeriodicalIF":4.1000,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11882797/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"npj aging","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1038/s41514-025-00206-3","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"GERIATRICS & GERONTOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

In the subterranean rodent (Nanno)spalax galili, evolutionary adaptation to hypoxia is correlated with longevity and tumor resistance. Adapted gene-regulatory networks of Spalax might pinpoint strategies to maintain health in humans. Comparing liver, kidney and spleen transcriptome data from Spalax and rat at hypoxia and normoxia, we identified differentially expressed gene pathways common to multiple organs in both species. Body-wide interspecies differences affected processes like cell death, antioxidant defense, DNA repair, energy metabolism, immune response and angiogenesis, which may play a crucial role in Spalax's adaptation to environmental hypoxia. In all organs, transcription of genes for genome stability maintenance and DNA repair was elevated in Spalax versus rat, accompanied by lower expression of aerobic energy metabolism and proinflammatory genes. These transcriptomic changes might account for the extraordinary lifespan of Spalax and its cancer resistance. The identified gene networks present candidates for further investigating the molecular basis underlying the complex Spalax phenotype.

Spalax galili转录组对缺氧的适应可能是长寿和抗癌的复杂表型的基础。
在地下啮齿类动物(Nanno)spalax galili中,对缺氧的进化适应与长寿和抗肿瘤有关。Spalax的适应性基因调控网络可能会找到维持人类健康的策略。通过比较Spalax和大鼠在缺氧和常氧条件下的肝脏、肾脏和脾脏转录组数据,我们发现了两种物种中多个器官共有的差异表达基因通路。全身物种间差异影响细胞死亡、抗氧化防御、DNA修复、能量代谢、免疫反应和血管生成等过程,这可能在Spalax适应环境缺氧中起关键作用。在所有器官中,Spalax与大鼠相比,基因组稳定维持和DNA修复基因的转录均升高,同时有氧能量代谢和促炎基因的表达降低。这些转录组的变化可能解释了Spalax超长的寿命和它的抗癌能力。已确定的基因网络为进一步研究复杂Spalax表型的分子基础提供了候选基因。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
CiteScore
8.90
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信